Recent ultrasound advancements for the manipulation of nanobiomaterials and nanoformulations for drug delivery

Shin Low, Sze; Nong Lim, Chang; Yew, Maxine; Siong Chai, Wai; Ee Low, Liang; Manickam, Sivakumar; Ti Tey, Beng; Loke Show, Pau

Abstract

Recent advances in ultrasound (US) have shown its great potential in biomedical applications as diagnostic and therapeutic tools. The coupling of ultrasound-assisted drug delivery systems with nanobiomaterials possessing tailor-made functions has been shown to remove the limitations of conventional drug delivery systems. The low-frequency ultrasound has significantly enhanced the targeted drug delivery effect and efficacy, reducing limitations posed by conventional treatments such as a limited therapeutic window. The acoustic cavitation effect induced by the ultrasound-mediated microbubbles (MBs) has been reported to replace drugs in certain acute diseases like ischemic stroke. This review briefly discusses the ultrasound principles, with particular attention to the recent advancements in drug delivery applications. Furthermore, ultrasound-assisted drug delivery coupled with nanobiomaterials to treat different diseases (cancer, neurodegenerative disease, diabetes, thrombosis and COVID-19) is discussed. Finally, this review covers the future perspectives and challenges on the applications of ultrasound-mediated nanobiomaterials.

Citation

Shin Low, S., Low, S., Nong Lim, C., Yew, M., Siong Chai, W., Chai, W., Ee Low, L., Low, L., Manickam, S., Ti Tey, B., Tey, B., Loke Show, P., & Show, P. (2021). Recent ultrasound advancements for the manipulation of nanobiomaterials and nanoformulations for drug delivery. Ultrasonics Sonochemistry, 80, Article 105805. https://doi.org/10.1016/j.ultsonch.2021.105805

• Journal Article Type: Article
• Acceptance Date: Oct 20, 2021
• Online Publication Date: Oct 24, 2021
• Publication Date: 2021-12
• Deposit Date: Jul 25, 2023
• Publicly Available Date: Jul 27, 2023
• Journal: Ultrasonics Sonochemistry
• Print ISSN: 1350-4177
• Electronic ISSN: 1873-2828
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 80
• Article Number: 105805
• DOI: https://doi.org/10.1016/j.ultsonch.2021.105805
• Keywords: Acoustics and Ultrasonics; Radiology, Nuclear Medicine and imaging; Chemical Engineering (miscellaneous); Inorganic Chemistry; Organic Chemistry; Environmental Chemistry
• Public URL: https://nottingham-repository.worktribe.com/output/23220074
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S1350417721003473?via%3Dihub