Skip to main content

Research Repository

Advanced Search

Imaging characteristics of H3 K27M histone-mutant diffuse midline glioma in teenagers and adults

Thust, Stefanie; Micallef, Caroline; Okuchi, Sachi; Brandner, Sebastian; Kumar, Atul; Mankad, Kshitij; Wastling, Stephen; Mancini, Laura; Jäger, Hans Rolf; Shankar, Ananth

Imaging characteristics of H3 K27M histone-mutant diffuse midline glioma in teenagers and adults Thumbnail


Authors

Stefanie Thust

Caroline Micallef

Sachi Okuchi

Sebastian Brandner

Atul Kumar

Kshitij Mankad

Stephen Wastling

Laura Mancini

Hans Rolf Jäger

Ananth Shankar



Abstract

Background:

To assess anatomical and quantitative diffusion-weighted MR imaging features in a recently classified lethal neoplasm, H3 K27M histone-mutant diffuse midline glioma [World Health Organization (WHO) IV].

Methods:

Fifteen untreated gliomas in teenagers and adults (median age 19, range, 14-64) with confirmed H3 K27M histone-mutant genotype were analysed at a national referral centre. Morphological characteristics including tumour epicentre(s), T2/FLAIR and Gadolinium enhancement patterns, calcification, haemorrhage and cyst formation were recorded. Multiple apparent diffusion coefficient (ADCmin, ADCmean) regions of interest were sited in solid tumour and normal appearing white matter (ADCNAWM) using post-processing software (Olea Sphere v2.3, Olea Medical). ADC histogram data (2nd, 5th, 10th percentile, median, mean, kurtosis, skewness) were calculated from volumetric tumour segmentations and tested against the regions of interest (ROI) data (Wilcoxon signed rank test).

Results:

The median interval from imaging to tissue diagnosis was 9 (range, 0-74) days. The structural MR imaging findings varied between individuals and within tumours, often featuring signal heterogeneity on all MR sequences. All gliomas demonstrated contact with the brain midline, and 67% exhibited rim-enhancing necrosis. The mean ROI ADCmin value was 0.84 (±0.15 standard deviation, SD) ×10−3 mm2/s. In the largest tumour cross-section (excluding necrosis), an average ADCmean value of 1.12 (±0.25)×10−3 mm2/s was observed. The mean ADCmin/NAWM ratio was 1.097 (±0.149), and the mean ADCmean/NAWM ratio measured 1.466 (±0.299). With the exception of the 2nd centile, no statistical difference was observed between the regional and histogram derived ADC results.

Conclusions:

H3 K27M-mutant gliomas demonstrate variable morphology and diffusivity, commonly featuring moderately low ADC values in solid tumour. Regional ADC measurements appeared representative of volumetric histogram data in this study.

Citation

Thust, S., Micallef, C., Okuchi, S., Brandner, S., Kumar, A., Mankad, K., Wastling, S., Mancini, L., Jäger, H. R., & Shankar, A. (2021). Imaging characteristics of H3 K27M histone-mutant diffuse midline glioma in teenagers and adults. Quantitative Imaging in Medicine and Surgery, 11(1), 43-56. https://doi.org/10.21037/QIMS-19-954

Journal Article Type Article
Acceptance Date Jul 7, 2020
Online Publication Date Jan 1, 2021
Publication Date Jan 1, 2021
Deposit Date May 7, 2025
Publicly Available Date May 8, 2025
Journal Quantitative Imaging in Medicine and Surgery
Print ISSN 2223-4292
Electronic ISSN 2223-4306
Peer Reviewed Peer Reviewed
Volume 11
Issue 1
Pages 43-56
DOI https://doi.org/10.21037/QIMS-19-954
Public URL https://nottingham-repository.worktribe.com/output/20567537
Publisher URL https://qims.amegroups.org/article/view/51179/html
PMID 33392010

Files





You might also like



Downloadable Citations