Early MRI Predictors of Relapse in Primary Central Nervous System Lymphoma Treated with MATRix Immunochemotherapy

Cornell, Isabel; Al Busaidi, Ayisha; Wastling, Stephen; Anjari, Mustafa; Cwynarski, Kate; Fox, Christopher P.; Martinez-Calle, Nicolas; Poynton, Edward; Maynard, John; Thust, Steffi C.

Abstract

Primary Central Nervous System Lymphoma (PCNSL) is a highly malignant brain tumour. We investigated dynamic changes in tumour volume and apparent diffusion coefficient (ADC) measurements for predicting outcome following treatment with MATRix chemotherapy in PCNSL. Patients treated with MATRix (n = 38) underwent T1 contrast-enhanced (T1CE) and diffusion-weighted imaging (DWI) before treatment, after two cycles and after four cycles of chemotherapy. Response was assessed using the International PCNSL Collaborative Group (IPCG) imaging criteria. ADC histogram parameters and T1CE tumour volumes were compared among response groups, using one-way ANOVA testing. Logistic regression was performed to examine those imaging parameters predictive of response. Response after two cycles of chemotherapy differed from response after four cycles; of the six patients with progressive disease (PD) after four cycles of treatment, two (33%) had demonstrated a partial response (PR) or complete response (CR) after two cycles. ADCmean at baseline, T1CE at baseline and T1CE percentage volume change differed between response groups (0.005 < p < 0.038) and were predictive of MATRix treatment response (area under the curve: 0.672–0.854). Baseline ADC and T1CE metrics are potential biomarkers for risk stratification of PCNSL patients early during remission induction therapy with MATRix. Standard interim response assessment (after two cycles) according to IPCG imaging criteria does not reliably predict early disease progression in the context of a conventional treatment approach.

Citation

Cornell, I., Al Busaidi, A., Wastling, S., Anjari, M., Cwynarski, K., Fox, C. P., Martinez-Calle, N., Poynton, E., Maynard, J., & Thust, S. C. (2023). Early MRI Predictors of Relapse in Primary Central Nervous System Lymphoma Treated with MATRix Immunochemotherapy. Journal of Personalized Medicine, 13(7), Article 1182. https://doi.org/10.3390/jpm13071182

• Journal Article Type: Article
• Acceptance Date: Jul 17, 2023
• Online Publication Date: Jul 24, 2023
• Publication Date: Jul 24, 2023
• Deposit Date: Sep 20, 2023
• Publicly Available Date: Sep 20, 2023
• Journal: Journal of Personalized Medicine
• Electronic ISSN: 2075-4426
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 13
• Issue: 7
• Article Number: 1182
• DOI: https://doi.org/10.3390/jpm13071182
• Public URL: https://nottingham-repository.worktribe.com/output/23861555
• Publisher URL: https://www.mdpi.com/2075-4426/13/7/1182