Filtration-Histogram Based Magnetic Resonance Texture Analysis (MRTA) for the Distinction of Primary Central Nervous System Lymphoma and Glioblastoma

MacIver, Claire L.; Al Busaidi, Ayisha; Ganeshan, Balaji; Maynard, John A.; Wastling, Stephen; Hyare, Harpreet; Brandner, Sebastian; Markus, Julia E.; Lewis, Martin A.; Groves, Ashley M.; Cwynarski, Kate; Thust, Stefanie C.

Abstract

Primary central nervous system lymphoma (PCNSL) has variable imaging appearances, which overlap with those of glioblastoma (GBM), thereby necessitating invasive tissue diagnosis. We aimed to investigate whether a rapid filtration histogram analysis of clinical MRI data supports the distinction of PCNSL from GBM. Ninety tumours (PCNSL n = 48, GBM n = 42) were analysed using pre‐treatment MRI sequences (T1‐weighted contrast‐enhanced (T1CE), T2‐weighted (T2), and apparent diffusion coefficient maps (ADC)). The segmentations were completed with proprietary texture analysis software (TexRAD version 3.3). Filtered (five filter sizes SSF = 2–6 mm) and unfil-tered (SSF = 0) histogram parameters were compared using Mann‐Whitney U non‐parametric test-ing, with receiver operating characteristic (ROC) derived area under the curve (AUC) analysis for significant results. Across all (n = 90) tumours, the optimal algorithm performance was achieved using an unfiltered ADC mean and the mean of positive pixels (MPP), with a sensitivity of 83.8%, specificity of 8.9%, and AUC of 0.88. For subgroup analysis with >1/3 necrosis masses, ADC permit-ted the identification of PCNSL with a sensitivity of 96.9% and specificity of 100%. For T1CE‐derived regions, the distinction was less accurate, with a sensitivity of 71.4%, specificity of 77.1%, and AUC of 0.779. A role may exist for cross‐sectional texture analysis without complex machine learning models to differentiate PCNSL from GBM. ADC appears the most suitable sequence, especially for necrotic lesion distinction.

Citation

MacIver, C. L., Al Busaidi, A., Ganeshan, B., Maynard, J. A., Wastling, S., Hyare, H., Brandner, S., Markus, J. E., Lewis, M. A., Groves, A. M., Cwynarski, K., & Thust, S. C. (2021). Filtration-Histogram Based Magnetic Resonance Texture Analysis (MRTA) for the Distinction of Primary Central Nervous System Lymphoma and Glioblastoma. Journal of Personalized Medicine, 11(9), Article 876. https://doi.org/10.3390/jpm11090876

• Journal Article Type: Article
• Acceptance Date: Aug 24, 2021
• Online Publication Date: Aug 31, 2021
• Publication Date: Aug 31, 2021
• Deposit Date: May 7, 2025
• Publicly Available Date: May 8, 2025
• Journal: Journal of Personalized Medicine
• Electronic ISSN: 2075-4426
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 11
• Issue: 9
• Article Number: 876
• DOI: https://doi.org/10.3390/jpm11090876
• Keywords: brain; lymphoma; glioblastoma; magnetic resonance imaging; computer-assisted
• Public URL: https://nottingham-repository.worktribe.com/output/20567534
• Publisher URL: https://www.mdpi.com/2075-4426/11/9/876
• PMID: 34575653