Human vascular cell responses to the circulating bone hormone osteocalcin

Millar, Sophie A.; Anderson, Susan I.; O'sullivan, Saoirse E.

Abstract

The purpose of this study was to characterize the direct effects of uncarboxylated osteocalcin (ucOCN) on vascular cell biology in vitro, to assess its potential function in pathophysiological conditions such as atherosclerosis. Human aortic endothelial cells (HAECs) and smooth muscle cells (HASMCs) were treated with ucOCN (0.1–50 ng/ml) and changes in phosphorylation of intracellular signaling proteins, angiogenesis, proliferation, migration, monolayer permeability, and protein secretion were measured. In HAECs, phosphorylated JNK and CREB were decreased with ucOCN (p 

Citation

Millar, S. A., Anderson, S. I., & O'sullivan, S. E. (2019). Human vascular cell responses to the circulating bone hormone osteocalcin. Journal of Cellular Physiology, 234(11), 21039-21048. https://doi.org/10.1002/jcp.28707

• Journal Article Type: Article
• Acceptance Date: Apr 10, 2019
• Online Publication Date: Apr 26, 2019
• Publication Date: Apr 26, 2019
• Deposit Date: May 2, 2019
• Publicly Available Date: May 2, 2019
• Journal: Journal of Cellular Physiology
• Print ISSN: 0021-9541
• Electronic ISSN: 1097-4652
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 234
• Issue: 11
• Pages: 21039-21048
• DOI: https://doi.org/10.1002/jcp.28707
• Keywords: AKT; aortic endothelial cells; ERK; osteocalcin; p70s6k
• Public URL: https://nottingham-repository.worktribe.com/output/2015359
• Publisher URL: https://onlinelibrary.wiley.com/doi/full/10.1002/jcp.28707
• Contract Date: May 2, 2019