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Human vascular cell responses to the circulating bone hormone osteocalcin

Millar, Sophie A.; Anderson, Susan I.; O'sullivan, Saoirse E.


Sophie A. Millar

Saoirse E. O'sullivan


The purpose of this study was to characterize the direct effects of uncarboxylated osteocalcin (ucOCN) on vascular cell biology in vitro, to assess its potential function in pathophysiological conditions such as atherosclerosis. Human aortic endothelial cells (HAECs) and smooth muscle cells (HASMCs) were treated with ucOCN (0.1–50 ng/ml) and changes in phosphorylation of intracellular signaling proteins, angiogenesis, proliferation, migration, monolayer permeability, and protein secretion were measured. In HAECs, phosphorylated JNK and CREB were decreased with ucOCN (p 


Millar, S. A., Anderson, S. I., & O'sullivan, S. E. (2019). Human vascular cell responses to the circulating bone hormone osteocalcin. Journal of Cellular Physiology, 234(11), 21039-21048.

Journal Article Type Article
Acceptance Date Apr 10, 2019
Online Publication Date Apr 26, 2019
Publication Date Apr 26, 2019
Deposit Date May 2, 2019
Publicly Available Date May 2, 2019
Journal Journal of Cellular Physiology
Print ISSN 0021-9541
Electronic ISSN 1097-4652
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 234
Issue 11
Pages 21039-21048
Keywords AKT; aortic endothelial cells; ERK; osteocalcin; p70s6k
Public URL
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