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Human vascular cell responses to the circulating bone hormone osteocalcin

Millar, Sophie A.; Anderson, Susan I.; O'sullivan, Saoirse E.

Authors

Sophie A. Millar

Saoirse E. O'sullivan



Abstract

The purpose of this study was to characterize the direct effects of uncarboxylated osteocalcin (ucOCN) on vascular cell biology in vitro, to assess its potential function in pathophysiological conditions such as atherosclerosis. Human aortic endothelial cells (HAECs) and smooth muscle cells (HASMCs) were treated with ucOCN (0.1–50 ng/ml) and changes in phosphorylation of intracellular signaling proteins, angiogenesis, proliferation, migration, monolayer permeability, and protein secretion were measured. In HAECs, phosphorylated JNK and CREB were decreased with ucOCN (p 

Journal Article Type Article
Publication Date Apr 26, 2019
Journal Journal of Cellular Physiology
Print ISSN 0021-9541
Electronic ISSN 1097-4652
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 234
Issue 11
Pages 21039-21048
APA6 Citation Millar, S. A., Anderson, S. I., & O'sullivan, S. E. (2019). Human vascular cell responses to the circulating bone hormone osteocalcin. Journal of Cellular Physiology, 234(11), 21039-21048. https://doi.org/10.1002/jcp.28707
DOI https://doi.org/10.1002/jcp.28707
Keywords AKT; aortic endothelial cells; ERK; osteocalcin; p70s6k
Publisher URL https://onlinelibrary.wiley.com/doi/full/10.1002/jcp.28707

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