Complex roles of TGF-beta signaling pathways in lung development and bronchopulmonary dysplasia

Calthorpe, Rebecca J.; Poulter, Caroline; Smyth, Alan R.; Sharkey, Don; Bhatt, Jayesh; Jenkins, Gisli; Tatler, Amanda L.

doi:10.1152/ajplung.00106.2021

Authors

Rebecca J. Calthorpe

Caroline Poulter

ALAN SMYTH alan.smyth@nottingham.ac.uk
Professor of Child Health

DON SHARKEY don.sharkey@nottingham.ac.uk
Professor of Neonatal Medicine and Technologies

Jayesh Bhatt

Gisli Jenkins

AMANDA TATLER AMANDA.TATLER@NOTTINGHAM.AC.UK
Principal Research Fellow

Abstract

As survival of extremely preterm infants continues to improve, there is also an associated increase in bronchopulmonary dysplasia (BPD), one of the most significant complications of preterm birth. BPD development is multifactorial resulting from exposure to multiple antenatal and postnatal stressors. BPD has both short-term health implications and long-term sequelae including increased respiratory, cardiovascular and neurological morbidity. Transforming growth factor beta (TGF-b) is an important signaling pathway in lung development, organ injury and fibrosis and is implicated in the development of BPD. This review provides a detailed account on the role of TGF-b in antenatal and postnatal lung development, the effect of known risk factors for BPD on the TGF-b signaling pathway, and how medications currently in use or under development, for the prevention or treatment of BPD, affect TGF-b signaling.

Citation

Calthorpe, R. J., Poulter, C., Smyth, A. R., Sharkey, D., Bhatt, J., Jenkins, G., & Tatler, A. L. (2023). Complex roles of TGF-beta signaling pathways in lung development and bronchopulmonary dysplasia. AJP - Lung Cellular and Molecular Physiology, 324(3), L285-L296. https://doi.org/10.1152/ajplung.00106.2021

Journal Article Type	Article
Acceptance Date	Jan 9, 2023
Online Publication Date	Jan 10, 2023
Publication Date	2023-03
Deposit Date	Jan 12, 2023
Publicly Available Date	Jan 12, 2023
Journal	American Journal of Physiology-Lung Cellular and Molecular Physiology
Print ISSN	1040-0605
Electronic ISSN	1522-1504
Publisher	American Physiological Society
Peer Reviewed	Peer Reviewed
Volume	324
Issue	3
Pages	L285-L296
DOI	https://doi.org/10.1152/ajplung.00106.2021
Keywords	Cell Biology, Physiology (medical), Pulmonary and Respiratory Medicine, Physiology
Public URL	https://nottingham-repository.worktribe.com/output/15935412
Publisher URL	https://journals.physiology.org/doi/abs/10.1152/ajplung.00106.2021