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Complex roles of TGF-beta signaling pathways in lung development and bronchopulmonary dysplasia

Calthorpe, Rebecca J.; Poulter, Caroline; Smyth, Alan R.; Sharkey, Don; Bhatt, Jayesh; Jenkins, Gisli; Tatler, Amanda L.


Rebecca J. Calthorpe

Caroline Poulter

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Professor of Child Health

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Professor of Neonatal Medicine and Technologies

Jayesh Bhatt

Gisli Jenkins


As survival of extremely preterm infants continues to improve, there is also an associated increase in bronchopulmonary dysplasia (BPD), one of the most significant complications of preterm birth. BPD development is multifactorial resulting from exposure to multiple antenatal and postnatal stressors. BPD has both short-term health implications and long-term sequelae including increased respiratory, cardiovascular and neurological morbidity. Transforming growth factor beta (TGF-b) is an important signaling pathway in lung development, organ injury and fibrosis and is implicated in the development of BPD. This review provides a detailed account on the role of TGF-b in antenatal and postnatal lung development, the effect of known risk factors for BPD on the TGF-b signaling pathway, and how medications currently in use or under development, for the prevention or treatment of BPD, affect TGF-b signaling.


Calthorpe, R. J., Poulter, C., Smyth, A. R., Sharkey, D., Bhatt, J., Jenkins, G., & Tatler, A. L. (2023). Complex roles of TGF-beta signaling pathways in lung development and bronchopulmonary dysplasia. AJP - Lung Cellular and Molecular Physiology, 324(3), L285-L296.

Journal Article Type Article
Acceptance Date Jan 9, 2023
Online Publication Date Jan 10, 2023
Publication Date 2023-03
Deposit Date Jan 12, 2023
Publicly Available Date Jan 12, 2023
Journal American Journal of Physiology-Lung Cellular and Molecular Physiology
Print ISSN 1040-0605
Electronic ISSN 1522-1504
Publisher American Physiological Society
Peer Reviewed Peer Reviewed
Volume 324
Issue 3
Pages L285-L296
Keywords Cell Biology, Physiology (medical), Pulmonary and Respiratory Medicine, Physiology
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