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Complex roles of TGF-β signaling pathways in lung development and bronchopulmonary dysplasia

Calthorpe, Rebecca J.; Poulter, Caroline; Smyth, Alan R.; Sharkey, Don; Bhatt, Jayesh; Jenkins, Gisli; Tatler, Amanda L.

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Authors

Rebecca J. Calthorpe

Caroline Poulter

Alan R. Smyth

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DON SHARKEY don.sharkey@nottingham.ac.uk
Professor of Neonatal Medicine and Technologies

Jayesh Bhatt

Gisli Jenkins

AMANDA TATLER AMANDA.TATLER@NOTTINGHAM.AC.UK
Principal Research Fellow



Abstract

As survival of extremely preterm infants continues to improve, there is also an associated increase in bronchopulmonary dysplasia (BPD), one of the most significant complications of preterm birth. BPD development is multifactorial resulting from exposure to multiple antenatal and postnatal stressors. BPD has both short-term health implications and long-term sequelae including increased respiratory, cardiovascular, and neurological morbidity. Transforming growth factor β (TGF-β) is an important signaling pathway in lung development, organ injury, and fibrosis and is implicated in the development of BPD. This review provides a detailed account on the role of TGF-β in antenatal and postnatal lung development, the effect of known risk factors for BPD on the TGF-β signaling pathway, and how medications currently in use or under development, for the prevention or treatment of BPD, affect TGF-β signaling.

Citation

Calthorpe, R. J., Poulter, C., Smyth, A. R., Sharkey, D., Bhatt, J., Jenkins, G., & Tatler, A. L. (2023). Complex roles of TGF-β signaling pathways in lung development and bronchopulmonary dysplasia. AJP - Lung Cellular and Molecular Physiology, 324(3), L285-L296. https://doi.org/10.1152/ajplung.00106.2021

Journal Article Type Review
Acceptance Date Jan 9, 2023
Online Publication Date Mar 6, 2023
Publication Date Mar 1, 2023
Deposit Date Jan 12, 2023
Publicly Available Date Mar 28, 2024
Journal AJP - Lung Cellular and Molecular Physiology
Print ISSN 1040-0605
Electronic ISSN 1522-1504
Publisher American Physiological Society
Peer Reviewed Peer Reviewed
Volume 324
Issue 3
Pages L285-L296
DOI https://doi.org/10.1152/ajplung.00106.2021
Keywords Bronchopulmonary dysplasia; transforming growth factor-β
Public URL https://nottingham-repository.worktribe.com/output/15935412
Publisher URL https://journals.physiology.org/doi/abs/10.1152/ajplung.00106.2021

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