Complex roles of TGF-β signaling pathways in lung development and bronchopulmonary dysplasia

Calthorpe, Rebecca J.; Poulter, Caroline; Smyth, Alan R.; Sharkey, Don; Bhatt, Jayesh; Jenkins, Gisli; Tatler, Amanda L.

Abstract

As survival of extremely preterm infants continues to improve, there is also an associated increase in bronchopulmonary dysplasia (BPD), one of the most significant complications of preterm birth. BPD development is multifactorial resulting from exposure to multiple antenatal and postnatal stressors. BPD has both short-term health implications and long-term sequelae including increased respiratory, cardiovascular, and neurological morbidity. Transforming growth factor β (TGF-β) is an important signaling pathway in lung development, organ injury, and fibrosis and is implicated in the development of BPD. This review provides a detailed account on the role of TGF-β in antenatal and postnatal lung development, the effect of known risk factors for BPD on the TGF-β signaling pathway, and how medications currently in use or under development, for the prevention or treatment of BPD, affect TGF-β signaling.

Citation

Calthorpe, R. J., Poulter, C., Smyth, A. R., Sharkey, D., Bhatt, J., Jenkins, G., & Tatler, A. L. (2023). Complex roles of TGF-β signaling pathways in lung development and bronchopulmonary dysplasia. AJP - Lung Cellular and Molecular Physiology, 324(3), L285-L296. https://doi.org/10.1152/ajplung.00106.2021

• Journal Article Type: Review
• Acceptance Date: Jan 9, 2023
• Online Publication Date: Mar 6, 2023
• Publication Date: Mar 1, 2023
• Deposit Date: Jan 12, 2023
• Publicly Available Date: Jan 12, 2023
• Journal: AJP - Lung Cellular and Molecular Physiology
• Print ISSN: 1040-0605
• Electronic ISSN: 1522-1504
• Publisher: American Physiological Society
• Peer Reviewed: Peer Reviewed
• Volume: 324
• Issue: 3
• Pages: L285-L296
• DOI: https://doi.org/10.1152/ajplung.00106.2021
• Keywords: Bronchopulmonary dysplasia; transforming growth factor-β
• Public URL: https://nottingham-repository.worktribe.com/output/15935412
• Publisher URL: https://journals.physiology.org/doi/abs/10.1152/ajplung.00106.2021