Skip to main content

Research Repository

Advanced Search

Effectiveness and cost-effectiveness of a Yoga-based Cardiac Rehabilitation (Yoga-CaRe) program following acute myocardial infarction: study rationale and design of a multi-centre randomized controlled trial

Chandrasekaran, Ambalam M.; Kinra, Sanjay; Ajay, Vamadevan S.; Chattopadhyay, Kaushik; Singh, Kalpana; Singh, Kavita; Praveen, Pradeep A.; Soni, Divya; Devarajan, Raji; Kondal, Dimple; Manchanda, Subhash C.; Hughes, Alun D.; Chaturvedi, Nishi; Roberts, Ian; Pocock, Stuart; Ebrahim, Shah; Reddy, Kolli S.; Tandon, Nikhil; Prabhakaran, Dorairaj; Yoga-CaRe Trial Team

Authors

Ambalam M. Chandrasekaran

Sanjay Kinra

Vamadevan S. Ajay

Kalpana Singh

Kavita Singh

Pradeep A. Praveen

Divya Soni

Raji Devarajan

Dimple Kondal

Subhash C. Manchanda

Alun D. Hughes

Nishi Chaturvedi

Ian Roberts

Stuart Pocock

Shah Ebrahim

Kolli S. Reddy

Nikhil Tandon

Dorairaj Prabhakaran

Yoga-CaRe Trial Team



Abstract

© 2019 Background: Cardiac rehabilitation (CR) is a standard treatment for secondary prevention of acute myocardial infarction (AMI) in high income countries (HICs), but it is inaccessible to most patients in India due to high costs and skills required for multidisciplinary CR teams. We developed a low-cost and scalable CR program based on culturally-acceptable practice of yoga (Yoga-CaRe). In this paper, we report the rationale and design for evaluation of its effectiveness and cost-effectiveness. Methods: This is a multi-center, single-blind, two-arm parallel-group randomized controlled trial across 22 cardiac care hospitals in India. Four thousand patients aged 18–80 years with AMI will be recruited and randomized 1:1 to receive Yoga-CaRe program (13 sessions supervised by an instructor and encouragement to self-practice daily) or enhanced standard care (3 sessions of health education) delivered over a period of three months. Participants will be followed 3-monthly till the end of the trial. The co-primary outcomes are a) time to occurrence of first cardiovascular event (composite of all-cause mortality, non-fatal myocardial infarction, non-fatal stroke and emergency cardiovascular hospitalization), and b) quality of life (Euro-QoL-5L) at 12 weeks. Secondary outcomes include need for revascularization procedures, return to pre-infarct activities, tobacco cessation, medication adherence, and cost-effectiveness of the intervention. Conclusion: This trial will alone contribute >20% participants to existing meta-analyses of randomized trials of CR worldwide. If Yoga-CaRe is found to be effective, it has the potential to save millions of lives and transform care of AMI patients in India and other low and middle income country settings.

Journal Article Type Article
Publication Date Apr 1, 2019
Journal International Journal of Cardiology
Print ISSN 0167-5273
Electronic ISSN 1874-1754
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 280
Pages 14-18
APA6 Citation Chandrasekaran, A. M., Kinra, S., Ajay, V. S., Chattopadhyay, K., Singh, K., Singh, K., …Yoga-CaRe Trial Team, . (2019). Effectiveness and cost-effectiveness of a Yoga-based Cardiac Rehabilitation (Yoga-CaRe) program following acute myocardial infarction: study rationale and design of a multi-centre randomized controlled trial. International Journal of Cardiology, 280, 14-18. https://doi.org/10.1016/j.ijcard.2019.01.012
DOI https://doi.org/10.1016/j.ijcard.2019.01.012
Keywords Cardiology and Cardiovascular Medicine
Publisher URL https://www.sciencedirect.com/science/article/pii/S016752731834539X
Additional Information This article is maintained by: Elsevier; Article Title: Effectiveness and cost-effectiveness of a Yoga-based Cardiac Rehabilitation (Yoga-CaRe) program following acute myocardial infarction: Study rationale and design of a multi-center randomized controlled trial; Journal Title: International Journal of Cardiology; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.ijcard.2019.01.012; Content Type: article; Copyright: © 2019 Published by Elsevier B.V.

Files





You might also like



Downloadable Citations

;