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How people wake up is associated with previous night’s sleep together with physical activity and food intake

Vallat, Raphael; Berry, Sarah E.; Tsereteli, Neli; Capdevila, Joan; Khatib, Haya Al; Valdes, Ana M.; Delahanty, Linda M.; Drew, David A.; Chan, Andrew T.; Wolf, Jonathan; Franks, Paul W.; Spector, Tim D.; Walker, Matthew P.


Raphael Vallat

Sarah E. Berry

Neli Tsereteli

Joan Capdevila

Haya Al Khatib

Linda M. Delahanty

David A. Drew

Andrew T. Chan

Jonathan Wolf

Paul W. Franks

Tim D. Spector

Matthew P. Walker


How people wake up and regain alertness in the hours after sleep is related to how they are sleeping, eating, and exercising. Here, in a prospective longitudinal study of 833 twins and genetically unrelated adults, we demonstrate that how effectively an individual awakens in the hours following sleep is not associated with their genetics, but instead, four independent factors: sleep quantity/quality the night before, physical activity the day prior, a breakfast rich in carbohydrate, and a lower blood glucose response following breakfast. Furthermore, an individual’s set-point of daily alertness is related to the quality of their sleep, their positive emotional state, and their age. Together, these findings reveal a set of non-genetic (i.e., not fixed) factors associated with daily alertness that are modifiable.


Vallat, R., Berry, S. E., Tsereteli, N., Capdevila, J., Khatib, H. A., Valdes, A. M., …Walker, M. P. (2022). How people wake up is associated with previous night’s sleep together with physical activity and food intake. Nature Communications, 13(1), Article 7116.

Journal Article Type Article
Acceptance Date Oct 27, 2022
Online Publication Date Nov 19, 2022
Publication Date Nov 19, 2022
Deposit Date Jan 13, 2023
Publicly Available Date Jan 13, 2023
Journal Nature Communications
Electronic ISSN 2041-1723
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 13
Issue 1
Article Number 7116
Keywords General Physics and Astronomy; General Biochemistry, Genetics and Molecular Biology; General Chemistry; Multidisciplinary
Public URL
Publisher URL


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