How people wake up is associated with previous night’s sleep together with physical activity and food intake

Vallat, Raphael; Berry, Sarah E.; Tsereteli, Neli; Capdevila, Joan; Khatib, Haya Al; Valdes, Ana M.; Delahanty, Linda M.; Drew, David A.; Chan, Andrew T.; Wolf, Jonathan; Franks, Paul W.; Spector, Tim D.; Walker, Matthew P.

Abstract

How people wake up and regain alertness in the hours after sleep is related to how they are sleeping, eating, and exercising. Here, in a prospective longitudinal study of 833 twins and genetically unrelated adults, we demonstrate that how effectively an individual awakens in the hours following sleep is not associated with their genetics, but instead, four independent factors: sleep quantity/quality the night before, physical activity the day prior, a breakfast rich in carbohydrate, and a lower blood glucose response following breakfast. Furthermore, an individual’s set-point of daily alertness is related to the quality of their sleep, their positive emotional state, and their age. Together, these findings reveal a set of non-genetic (i.e., not fixed) factors associated with daily alertness that are modifiable.

Citation

Vallat, R., Berry, S. E., Tsereteli, N., Capdevila, J., Khatib, H. A., Valdes, A. M., Delahanty, L. M., Drew, D. A., Chan, A. T., Wolf, J., Franks, P. W., Spector, T. D., & Walker, M. P. (2022). How people wake up is associated with previous night’s sleep together with physical activity and food intake. Nature Communications, 13(1), Article 7116. https://doi.org/10.1038/s41467-022-34503-2

• Journal Article Type: Article
• Acceptance Date: Oct 27, 2022
• Online Publication Date: Nov 19, 2022
• Publication Date: Nov 19, 2022
• Deposit Date: Jan 13, 2023
• Publicly Available Date: Jan 13, 2023
• Journal: Nature Communications
• Electronic ISSN: 2041-1723
• Publisher: Nature Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 13
• Issue: 1
• Article Number: 7116
• DOI: https://doi.org/10.1038/s41467-022-34503-2
• Keywords: General Physics and Astronomy; General Biochemistry, Genetics and Molecular Biology; General Chemistry; Multidisciplinary
• Public URL: https://nottingham-repository.worktribe.com/output/14025522
• Publisher URL: https://www.nature.com/articles/s41467-022-34503-2