How people wake up is associated with previous night’s sleep together with physical activity and food intake

Vallat, Raphael; Berry, Sarah E.; Tsereteli, Neli; Capdevila, Joan; Khatib, Haya Al; Valdes, Ana M.; Delahanty, Linda M.; Drew, David A.; Chan, Andrew T.; Wolf, Jonathan; Franks, Paul W.; Spector, Tim D.; Walker, Matthew P.

doi:10.1038/s41467-022-34503-2

How people wake up is associated with previous night’s sleep together with physical activity and food intake

Vallat, Raphael; Berry, Sarah E.; Tsereteli, Neli; Capdevila, Joan; Khatib, Haya Al; Valdes, Ana M.; Delahanty, Linda M.; Drew, David A.; Chan, Andrew T.; Wolf, Jonathan; Franks, Paul W.; Spector, Tim D.; Walker, Matthew P.

Authors

Raphael Vallat

Sarah E. Berry

Neli Tsereteli

Joan Capdevila

Haya Al Khatib

Professor ANA VALDES Ana.Valdes@nottingham.ac.uk
Professor of Molecular & Genetic Epidemiology

Linda M. Delahanty

David A. Drew

Andrew T. Chan

Jonathan Wolf

Paul W. Franks

Tim D. Spector

Matthew P. Walker

Abstract

How people wake up and regain alertness in the hours after sleep is related to how they are sleeping, eating, and exercising. Here, in a prospective longitudinal study of 833 twins and genetically unrelated adults, we demonstrate that how effectively an individual awakens in the hours following sleep is not associated with their genetics, but instead, four independent factors: sleep quantity/quality the night before, physical activity the day prior, a breakfast rich in carbohydrate, and a lower blood glucose response following breakfast. Furthermore, an individual’s set-point of daily alertness is related to the quality of their sleep, their positive emotional state, and their age. Together, these findings reveal a set of non-genetic (i.e., not fixed) factors associated with daily alertness that are modifiable.

Citation

Vallat, R., Berry, S. E., Tsereteli, N., Capdevila, J., Khatib, H. A., Valdes, A. M., …Walker, M. P. (2022). How people wake up is associated with previous night’s sleep together with physical activity and food intake. Nature Communications, 13(1), Article 7116. https://doi.org/10.1038/s41467-022-34503-2

Journal Article Type	Article
Acceptance Date	Oct 27, 2022
Online Publication Date	Nov 19, 2022
Publication Date	Nov 19, 2022
Deposit Date	Jan 13, 2023
Publicly Available Date	Jan 13, 2023
Journal	Nature Communications
Electronic ISSN	2041-1723
Publisher	Nature Publishing Group
Peer Reviewed	Peer Reviewed
Volume	13
Issue	1
Article Number	7116
DOI	https://doi.org/10.1038/s41467-022-34503-2
Keywords	General Physics and Astronomy; General Biochemistry, Genetics and Molecular Biology; General Chemistry; Multidisciplinary
Public URL	https://nottingham-repository.worktribe.com/output/14025522
Publisher URL	https://www.nature.com/articles/s41467-022-34503-2