Impact of meningococcal ACWY conjugate vaccines on pharyngeal carriage in adolescents: evidence for herd protection from the UK MenACWY programme

Carr, Jeremy P.; MacLennan, Jenny M.; Plested, Emma; Bratcher, Holly B.; Harrison, Odile B.; Aley, Parvinder K.; Bray, James E.; Camara, Susana; Rodrigues, Charlene M.C.; Davis, Kimberly; Bartolf, Angela; Baxter, David; Cameron, J. Claire; Cunningham, Richard; Faust, Saul N.; Fidler, Katy; Gowda, Rohit; Heath, Paul T.; Hughes, Stephen; Khajuria, Sujata; Orr, David; Raman, Mala; Smith, Andrew; Turner, David P.J.; Whittaker, Elizabeth; Williams, Christopher J.; Zipitis, Christos S.; Pollard, Andrew J.; Oliver, Jennifer; Morales-Aza, Begonia; Lekshmi, Aiswarya; Clark, Stephen A.; Borrow, Ray; Christensen, Hannah; Trotter, Caroline; Finn, Adam; Maiden, Martin C.; Snape, Matthew D.; Jolley, Keith A.; Ford, Karen; Roberts, Hannah; Palmer, Karen; Suggitt, Debbie; Pemberton, Nicola; Ray, Samantha; Wootton, Mandy; Ladhani, Shamez N.; Owens, Daniel; Cathie, Katrina; Royal, Simon; Oldfield, Neil; Ure, Roisin; Richards, Jennifer; Ramsay, Rebecca; Hill, Samantha Thomson; Duale, Kaltun

Abstract

Objective: Serogroup W and Y invasive meningococcal disease increased globally from 2000 onwards. Responding to a rapid increase in serogroup W clonal complex 11 (W:cc11) invasive meningococcal disease, the UK replaced an adolescent booster dose of meningococcal C conjugate vaccine with quadrivalent MenACWY conjugate vaccine in 2015. By 2018, the vaccine coverage in the eligible school cohorts aged 14 to 19 years was 84%. We assessed the impact of the MenACWY vaccination programme on meningococcal carriage. Methods: An observational study of culture-defined oropharyngeal meningococcal carriage prevalence before and after the start of the MenACWY vaccination programme in UK school students, aged 15 to 19 years, using two cross-sectional studies: 2014 to 2015 “UKMenCar4” and 2018 “Be on the TEAM” (ISRCTN75858406). Results: A total of 10 625 participants preimplementation and 13 434 postimplementation were included. Carriage of genogroups C, W, and Y (combined) decreased from 2.03 to 0.71% (OR 0.34 [95% CI 0.27–0.44], p < 0.001). Carriage of genogroup B meningococci did not change (1.26% vs 1.23% [95% CI 0.77–1.22], p = 0.80) and genogroup C remained rare (n = 7/10 625 vs 17/13 488, p = 0.135). The proportion of serogroup positive isolates (i.e. those expressing capsule) decreased for genogroup W by 53.8% (95% CI –5.0 to 79.8, p = 0.016) and for genogroup Y by 30.1% (95% CI 8.9–46·3, p = 0.0025). Discussion: The UK MenACWY vaccination programme reduced carriage acquisition of genogroup and serogroup Y and W meningococci and sustained low levels of genogroup C carriage. These data support the use of quadrivalent MenACWY conjugate vaccine for indirect (herd) protection.

Citation

Carr, J. P., MacLennan, J. M., Plested, E., Bratcher, H. B., Harrison, O. B., Aley, P. K., …Duale, K. (2022). Impact of meningococcal ACWY conjugate vaccines on pharyngeal carriage in adolescents: evidence for herd protection from the UK MenACWY programme. Clinical Microbiology and Infection, 28(12), 1649.e1-1649.e8. https://doi.org/10.1016/j.cmi.2022.07.004

• Journal Article Type: Article
• Acceptance Date: Jul 6, 2022
• Online Publication Date: Jul 12, 2022
• Publication Date: 2022-12
• Deposit Date: May 30, 2023
• Publicly Available Date: Jun 2, 2023
• Journal: Clinical Microbiology and Infection
• Print ISSN: 1198-743X
• Electronic ISSN: 1469-0691
• Publisher: Elsevier BV
• Peer Reviewed: Peer Reviewed
• Volume: 28
• Issue: 12
• Pages: 1649.e1-1649.e8
• DOI: https://doi.org/10.1016/j.cmi.2022.07.004
• Keywords: Meningococcal Disease, ACWY, Conjugate vaccines, Pharyngeal carriage, Adolescents, Neisseria meningitidis, Herd immunity
• Public URL: https://nottingham-repository.worktribe.com/output/13464584
• Publisher URL: https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(22)00368-8/fulltext
• Related Public URLs: https://www.sciencedirect.com/science/article/pii/S1198743X22003688