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Evaluating the effects of processing parameters on budesonide nanocrystals prepared by nanomilling

Olubi, Rebecca; Small, William; Burley, Jonathan; Bosquillon, Cynthia

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Authors

Rebecca Olubi

William Small



Abstract

The aim of this study was to optimise processing parameters in the preparation ofbudesonide nanocrystals by a miniature media milling process performed at labscale. Using Polysorbate 80 as the surfactant choice of stabilizer, the effectof milling bead size, milling time and stabilizer concentration on budesonideparticle size was determined. Particle size decreased with smaller milling beadsize and longer milling time. However, no significant further decrease was seenafter milling past 6 hours. Increasing Polysorbate 80 concentration led to anincrease in budesonide particle size. Future direction will incorporatestability study with the screening of optimal stabilizer choice.

Citation

Olubi, R., Small, W., Burley, J., & Bosquillon, C. (2022). Evaluating the effects of processing parameters on budesonide nanocrystals prepared by nanomilling. British Journal of Pharmacy, 7(2), S1-S2. https://doi.org/10.5920/bjpharm.1140

Journal Article Type Article
Acceptance Date Jul 7, 2022
Online Publication Date Nov 2, 2022
Publication Date Nov 2, 2022
Deposit Date Dec 22, 2022
Publicly Available Date Mar 28, 2024
Journal British Journal of Pharmacy
Electronic ISSN 2058-8356
Peer Reviewed Peer Reviewed
Volume 7
Issue 2
Article Number 1140
Pages S1-S2
DOI https://doi.org/10.5920/bjpharm.1140
Public URL https://nottingham-repository.worktribe.com/output/13449930
Publisher URL https://www.bjpharm.org.uk/article/id/1140/
Additional Information 2022 APS Special Issue

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