Evaluating the effects of processing parameters on budesonide nanocrystals prepared by nanomilling

Olubi, Rebecca; Small, William; Burley, Jonathan; Bosquillon, Cynthia

Abstract

The aim of this study was to optimise processing parameters in the preparation ofbudesonide nanocrystals by a miniature media milling process performed at labscale. Using Polysorbate 80 as the surfactant choice of stabilizer, the effectof milling bead size, milling time and stabilizer concentration on budesonideparticle size was determined. Particle size decreased with smaller milling beadsize and longer milling time. However, no significant further decrease was seenafter milling past 6 hours. Increasing Polysorbate 80 concentration led to anincrease in budesonide particle size. Future direction will incorporatestability study with the screening of optimal stabilizer choice.

Citation

Olubi, R., Small, W., Burley, J., & Bosquillon, C. (2022). Evaluating the effects of processing parameters on budesonide nanocrystals prepared by nanomilling. British Journal of Pharmacy, 7(2), S1-S2. https://doi.org/10.5920/bjpharm.1140

• Journal Article Type: Article
• Acceptance Date: Jul 7, 2022
• Online Publication Date: Nov 2, 2022
• Publication Date: Nov 2, 2022
• Deposit Date: Dec 22, 2022
• Publicly Available Date: Dec 22, 2022
• Journal: British Journal of Pharmacy
• Electronic ISSN: 2058-8356
• Publisher: University of Huddersfield Press
• Peer Reviewed: Peer Reviewed
• Volume: 7
• Issue: 2
• Article Number: 1140
• Pages: S1-S2
• DOI: https://doi.org/10.5920/bjpharm.1140
• Public URL: https://nottingham-repository.worktribe.com/output/13449930
• Publisher URL: https://www.bjpharm.org.uk/article/id/1140/
• Additional Information: 2022 APS Special Issue