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The association between dengue immunoglobulin G titres with previous clinical dengue infection and white cell counts in Cuban children: a population-based study

Suarez-Medina, Ramon; Venero-Fernández, Silvia Josefina; Batista-Gutierrez, Lourdes; de los Angeles Estrada-Rondon, Yanelis; Alfonso-Hernandez, Anadelis; Casanave-Guarnaluce, Dulcima; Sardinas-Baez, Nieves; Castillo-Aguilar, Ivette; Toro, Jorge Antonio Febles-del; Fogarty, Andrew W.; HINASIC (Historia Natural de la Sibilancia en Cuba/Natural History of Wheezing in Cuba) Study Group

Authors

Ramon Suarez-Medina

Silvia Josefina Venero-Fernández

Lourdes Batista-Gutierrez

Yanelis de los Angeles Estrada-Rondon

Anadelis Alfonso-Hernandez

Dulcima Casanave-Guarnaluce

Nieves Sardinas-Baez

Ivette Castillo-Aguilar

Jorge Antonio Febles-del Toro

ANDREW FOGARTY andrew.fogarty@nottingham.ac.uk
Clinical Associate Professor & Reader in Clinical Epidemiology

HINASIC (Historia Natural de la Sibilancia en Cuba/Natural History of Wheezing in Cuba) Study Group



Abstract

Background
The prevalence of dengue infection is increasing globally. There are few prospective population-based surveillance studies of the immunological and inflammatory consequences of exposure to dengue virus in young children.

Objective
To study the association between serologically confirmed prior medical diagnosis of dengue infection and blood measures of systemic inflammation with dengue virus immunoglobulin G levels.

Methods
A population-based study of healthy three-year old children living in Havana, Cuba.

Results
865 individuals provided a blood sample. Fourteen (1.6%) had a prior medical diagnosis of dengue infection, and 851 individuals had no prior medical diagnosis. There was no difference in the serum immunoglobulin G titres between these groups (Mann-Whitney test, p = 0.49). Total white cell count, blood neutrophil and eosinophil counts were linearly associated with a dengue immunoglobulin G value above the median value.

Conclusions
There was no difference between the dengue immunoglobulin G titres in young children who had previously had clinically proven dengue infection compared to those who had no diagnosis of prior infection. This may be a consequence of a relatively high prevalence of sub-clinical infection. A higher dengue immunoglobulin G level was positively associated with a range of inflammatory biomarkers, although these data cannot demonstrate a causal association.

Journal Article Type Article
Publication Date Nov 28, 2018
Electronic ISSN 1932-6203
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 13
Issue 11
Article Number e0207391
Pages 1-9
APA6 Citation Suarez-Medina, R., Venero-Fernández, S. J., Batista-Gutierrez, L., de los Angeles Estrada-Rondon, Y., Alfonso-Hernandez, A., Casanave-Guarnaluce, D., …HINASIC (Historia Natural de la Sibilancia en Cuba/Natural History of Wheezing in Cuba) Study Group, . (2018). The association between dengue immunoglobulin G titres with previous clinical dengue infection and white cell counts in Cuban children: a population-based study. PLoS ONE, 13(11), 1-9. https://doi.org/10.1371/journal.pone.0207391
DOI https://doi.org/10.1371/journal.pone.0207391
Publisher URL https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207391
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