The association between dengue immunoglobulin G titres with previous clinical dengue infection and white cell counts in Cuban children: a population-based study
Suarez-Medina, Ramon; Venero-Fernández, Silvia Josefina; Batista-Gutierrez, Lourdes; de los Angeles Estrada-Rondon, Yanelis; Alfonso-Hernandez, Anadelis; Casanave-Guarnaluce, Dulcima; Sardinas-Baez, Nieves; Castillo-Aguilar, Ivette; Toro, Jorge Antonio Febles-del; Fogarty, Andrew W.; HINASIC (Historia Natural de la Sibilancia en Cuba/Natural History of Wheezing in Cuba) Study Group
Silvia Josefina Venero-Fernández
Yanelis de los Angeles Estrada-Rondon
Jorge Antonio Febles-del Toro
ANDREW FOGARTY firstname.lastname@example.org
Clinical Associate Professor & Reader in Clinical Epidemiology
HINASIC (Historia Natural de la Sibilancia en Cuba/Natural History of Wheezing in Cuba) Study Group
The prevalence of dengue infection is increasing globally. There are few prospective population-based surveillance studies of the immunological and inflammatory consequences of exposure to dengue virus in young children.
To study the association between serologically confirmed prior medical diagnosis of dengue infection and blood measures of systemic inflammation with dengue virus immunoglobulin G levels.
A population-based study of healthy three-year old children living in Havana, Cuba.
865 individuals provided a blood sample. Fourteen (1.6%) had a prior medical diagnosis of dengue infection, and 851 individuals had no prior medical diagnosis. There was no difference in the serum immunoglobulin G titres between these groups (Mann-Whitney test, p = 0.49). Total white cell count, blood neutrophil and eosinophil counts were linearly associated with a dengue immunoglobulin G value above the median value.
There was no difference between the dengue immunoglobulin G titres in young children who had previously had clinically proven dengue infection compared to those who had no diagnosis of prior infection. This may be a consequence of a relatively high prevalence of sub-clinical infection. A higher dengue immunoglobulin G level was positively associated with a range of inflammatory biomarkers, although these data cannot demonstrate a causal association.
|Journal Article Type||Article|
|Publication Date||Nov 28, 2018|
|Publisher||Public Library of Science|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Suarez-Medina, R., Venero-Fernández, S. J., Batista-Gutierrez, L., de los Angeles Estrada-Rondon, Y., Alfonso-Hernandez, A., Casanave-Guarnaluce, D., …HINASIC (Historia Natural de la Sibilancia en Cuba/Natural History of Wheezing in Cuba) Study Group, . (2018). The association between dengue immunoglobulin G titres with previous clinical dengue infection and white cell counts in Cuban children: a population-based study. PLoS ONE, 13(11), 1-9. https://doi.org/10.1371/journal.pone.0207391|