Connexin 43 is an independent predictor of patient outcome in breast cancer patients

Chasampalioti, Maria; Green, Andrew R.; Ellis, Ian O.; Rakha, Emad A.; Jackson, Andrew M.; Spendlove, Ian; Ramage, Judith M.

doi:10.1007/s10549-018-5063-9

Connexin 43 is an independent predictor of patient outcome in breast cancer patients

Chasampalioti, Maria; Green, Andrew R.; Ellis, Ian O.; Rakha, Emad A.; Jackson, Andrew M.; Spendlove, Ian; Ramage, Judith M.

Authors

Maria Chasampalioti

ANDREW GREEN ANDREW.GREEN@NOTTINGHAM.AC.UK
Associate Professor

Professor IAN ELLIS IAN.ELLIS@NOTTINGHAM.AC.UK
Professor of Cancer Pathology

EMAD RAKHA Emad.Rakha@nottingham.ac.uk
Professor of Breast Cancer Pathology

ANDREW JACKSON ANDREW.JACKSON@NOTTINGHAM.AC.UK
Associate Professor

IAN SPENDLOVE IAN.SPENDLOVE@NOTTINGHAM.AC.UK
Associate Professor

JUDITH RAMAGE JUDITH.RAMAGE@NOTTINGHAM.AC.UK
Associate Professor

Abstract

Purpose

Gap junctions are specialized membrane structures that form channels between adjacent cells allowing cell communication. Gap junctions and specifically Connexin 43 (Cx43) are down-regulated in cancer; however, there are contrasting reports on how this effects breast cancer patient survival. This paper is the first large-scale tissue microarray analysis of Cx43 expression in breast cancer patients with an associated clinical long-term follow-up.

Methods

Using a validated TMA of 1118 primary breast cancers, coupled to a comprehensive database of clinicopathological variables, the expression levels and subcellular localisation of Cx43 was assessed by immunohistochemistry. Its impact in terms of survival, distant metastasis-free survival, and clinicopathological variables was determined.

Results

Patients whose tumors expressed high levels of Cx43 had significantly better survival (p?

Citation

Chasampalioti, M., Green, A. R., Ellis, I. O., Rakha, E. A., Jackson, A. M., Spendlove, I., & Ramage, J. M. (2019). Connexin 43 is an independent predictor of patient outcome in breast cancer patients. Breast Cancer Research and Treatment, 174(1), 93-102. https://doi.org/10.1007/s10549-018-5063-9

Journal Article Type	Article
Acceptance Date	Nov 16, 2018
Online Publication Date	Nov 24, 2018
Publication Date	Feb 28, 2019
Deposit Date	Nov 27, 2018
Publicly Available Date	Nov 28, 2018
Journal	Breast Cancer Research and Treatment
Print ISSN	0167-6806
Electronic ISSN	1573-7217
Publisher	Springer Verlag
Peer Reviewed	Peer Reviewed
Volume	174
Issue	1
Pages	93-102
DOI	https://doi.org/10.1007/s10549-018-5063-9
Keywords	Cancer Research; Oncology
Public URL	https://nottingham-repository.worktribe.com/output/1314028
Publisher URL	https://link.springer.com/article/10.1007%2Fs10549-018-5063-9