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Connexin 43 is an independent predictor of patient outcome in breast cancer patients

Chasampalioti, Maria; Green, Andrew R.; Ellis, Ian O.; Rakha, Emad A.; Jackson, Andrew M.; Spendlove, Ian; Ramage, Judith M.

Authors

Maria Chasampalioti

EMAD RAKHA Emad.Rakha@nottingham.ac.uk
Professor of Breast Cancer Pathology



Abstract

Purpose

Gap junctions are specialized membrane structures that form channels between adjacent cells allowing cell communication. Gap junctions and specifically Connexin 43 (Cx43) are down-regulated in cancer; however, there are contrasting reports on how this effects breast cancer patient survival. This paper is the first large-scale tissue microarray analysis of Cx43 expression in breast cancer patients with an associated clinical long-term follow-up.

Methods

Using a validated TMA of 1118 primary breast cancers, coupled to a comprehensive database of clinicopathological variables, the expression levels and subcellular localisation of Cx43 was assessed by immunohistochemistry. Its impact in terms of survival, distant metastasis-free survival, and clinicopathological variables was determined.

Results

Patients whose tumors expressed high levels of Cx43 had significantly better survival (p 

Citation

Chasampalioti, M., Green, A. R., Ellis, I. O., Rakha, E. A., Jackson, A. M., Spendlove, I., & Ramage, J. M. (2019). Connexin 43 is an independent predictor of patient outcome in breast cancer patients. Breast Cancer Research and Treatment, 174(1), 93-102. https://doi.org/10.1007/s10549-018-5063-9

Journal Article Type Article
Acceptance Date Nov 16, 2018
Online Publication Date Nov 24, 2018
Publication Date Feb 28, 2019
Deposit Date Nov 27, 2018
Publicly Available Date Nov 28, 2018
Journal Breast Cancer Research and Treatment
Print ISSN 0167-6806
Electronic ISSN 1573-7217
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 174
Issue 1
Pages 93-102
DOI https://doi.org/10.1007/s10549-018-5063-9
Keywords Cancer Research; Oncology
Public URL https://nottingham-repository.worktribe.com/output/1314028
Publisher URL https://link.springer.com/article/10.1007%2Fs10549-018-5063-9

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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/





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