@article { , title = {Connexin 43 is an independent predictor of patient outcome in breast cancer patients}, abstract = {Purpose Gap junctions are specialized membrane structures that form channels between adjacent cells allowing cell communication. Gap junctions and specifically Connexin 43 (Cx43) are down-regulated in cancer; however, there are contrasting reports on how this effects breast cancer patient survival. This paper is the first large-scale tissue microarray analysis of Cx43 expression in breast cancer patients with an associated clinical long-term follow-up. Methods Using a validated TMA of 1118 primary breast cancers, coupled to a comprehensive database of clinicopathological variables, the expression levels and subcellular localisation of Cx43 was assessed by immunohistochemistry. Its impact in terms of survival, distant metastasis-free survival, and clinicopathological variables was determined. Results Patients whose tumors expressed high levels of Cx43 had significantly better survival (p?}, doi = {10.1007/s10549-018-5063-9}, eissn = {1573-7217}, issn = {0167-6806}, issue = {1}, journal = {Breast Cancer Research and Treatment}, pages = {93-102}, publicationstatus = {Published}, publisher = {Springer Verlag}, url = {https://nottingham-repository.worktribe.com/output/1314028}, volume = {174}, keyword = {Cancer Research, Oncology}, year = {2019}, author = {Chasampalioti, Maria and Green, Andrew R. and Ellis, Ian O. and Rakha, Emad A. and Jackson, Andrew M. and Spendlove, Ian and Ramage, Judith M.} }