Prospective on using mid-infrared supercontinuum laser sources for in vivo spectral discrimination of disease

Seddon, Angela B.; Napier, Bruce; Lindsay, Ian; Lamrini, Samir; Moselund, Peter Morten; Stone, Nick; Bang, Ole; Farries, Mark

Abstract

Mid-infrared (MIR) fibre-optics may play a future role in in vivo diagnosis of disease, including cancer. Recently, we reported for the first time an optical fibre based broadband supercontinuum (SC) laser source spanning 1.3 to 13.4 μm wavelength to cover the spectral 'fingerprint region' of biological tissue. This work has catalysed the new field of fibre MIR-SC and now very bright sources equivalent to a 'few synchrotrons' have been demonstrated in fibre. In addition, we have made record transparency MIR fibre for routeing the MIR light and reported first-time MIR photoluminescence (with long lifetime) in small-core, rare earth ion doped, MIR fibre - an important step towards MIR fibre lasing at > 4 μm wavelength for pumping fibre MIR-SC. First time fibre MIR-SC spectroscopic imaging of colon tissue is described at wavelengths in the ‘fingerprint region’.

Citation

Seddon, A. B., Napier, B., Lindsay, I., Lamrini, S., Moselund, P. M., Stone, N., Bang, O., & Farries, M. (2018). Prospective on using mid-infrared supercontinuum laser sources for in vivo spectral discrimination of disease. Analyst, 143(24), 5874-5887. https://doi.org/10.1039/c8an01396a

• Journal Article Type: Article
• Acceptance Date: Nov 5, 2018
• Online Publication Date: Nov 5, 2018
• Publication Date: Nov 5, 2018
• Deposit Date: Nov 6, 2018
• Publicly Available Date: Nov 6, 2019
• Journal: The Analyst
• Print ISSN: 0003-2654
• Electronic ISSN: 1364-5528
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 143
• Issue: 24
• Pages: 5874-5887
• DOI: https://doi.org/10.1039/c8an01396a
• Keywords: Analytical chemistry; Spectroscopy; Electrochemistry; Biochemistry; Environmental chemistry
• Public URL: https://nottingham-repository.worktribe.com/output/1230793
• Publisher URL: https://pubs.rsc.org/en/Content/ArticleLanding/2018/AN/C8AN01396A#!divAbstract
• Contract Date: Nov 6, 2018