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Ion - reagent interactions contributing to ionic liquid solvent effects on a condensation reaction

Keaveney, Sinead Teresa; Harper, Jason Brian; Croft, Anna K.

Authors

Sinead Teresa Keaveney

Jason Brian Harper



Abstract

Molecular dynamics simulations of solutions of hexan-1-amine or 4-methoxybenzaldehyde in acetonitrile, an ionic liquid/ acetonitrile mixture (XIL = 0.2), and a number of different (neat) ionic liquids were performed, to further understand the solvent effects on the condensation reaction of these species. This work indicates that, in the presence of an ionic liquid, the amine group of hexan-1-amine is exclusively solvated by the compo- nents of the ionic liquid, and not by acetonitrile, and that the anion interacts with the aldehyde group of 4-methoxybenzalde- hyde. These interactions showed little dependence on the proportion of the ionic liquid present. When varying the cation of the ionic liquid there were changes in the cation–amine interaction, and 1-butyl-2,3-dimethylimidazolium bis (trifluoro-methanesulfonyl) imide ([Bm2im][N(CF3SO2)2]) was found to order more than expected about the amine. This ordering is likely the origin of the large rate constant values determined in [Bm2im][N(CF3SO2)2] for this condensation reaction and explains an anomaly seen previously. When changing the anion, changes were seen in the interactions between both the cation and anion with hexan-1-amine, and the anion with 4-methoxyben- zaldehyde. The differing magnitude of these interactions likely causes subtle changes in the activation parameters for this condensation reaction, and provides an explanation for the anomalous rate constant values previously determined when varying the anion.

Journal Article Type Article
Publication Date Oct 5, 2018
Journal ChemPhysChem
Print ISSN 1439-4235
Electronic ISSN 1439-7641
Publisher Wiley
Peer Reviewed Peer Reviewed
APA6 Citation Keaveney, S. T., Harper, J. B., & Croft, A. K. (2018). Ion - reagent interactions contributing to ionic liquid solvent effects on a condensation reaction. ChemPhysChem, https://doi.org/10.1002/cphc.201800695
DOI https://doi.org/10.1002/cphc.201800695
Keywords Ionic liquid; Molecular dynamics; Solvent effect; Interactions; Ordering
Publisher URL https://onlinelibrary.wiley.com/doi/abs/10.1002/cphc.201800695
Additional Information This is the peer reviewed version of the following article: Keaveney, S.., Harper, J. and Croft, A.. (2018), Ion ‐ reagent interactions contributing to ionic liquid solvent effects on a condensation reaction. ChemPhysChem., which has been published in final form at https://doi.org/10.1002/cphc.201800695. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
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