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PIAS? expression in relation to clinicopathological, tumour factors and survival in indigenous black breast cancer women

Agboola, Ayodeji; Musa, Adewale; Banjo, Adekumbiola; Ayoade, Babatunde; Deji-Agboola, Mopelola; Nolan, Christopher; Rakha, Emad; Ellis, Ian; Green, Andrew


Ayodeji Agboola

Adewale Musa

Adekumbiola Banjo

Babatunde Ayoade

Mopelola Deji-Agboola

Christopher Nolan

Professor of Breast Cancer Pathology


Aim: Indigenous black women with breast cancer (BC) show a high frequency of triple negative breast cancer (TNBC) comprising ER-, PR- and HER2- phenotypes and BRCA1 deficiency together with a high mortality rate, prompting speculation that risk factors could be genetic and the molecular portrait of these tumours may be different to those of Western women. Protein inhibitor of activated signal transducer (PIAS) ? implicated in the BRCA1 deficiency and triple negative BC was investigated to establish the relationship among the small ubiquitin-like modifier marker, pathological features, biomarkers expression and clinical outcome in the black women.

Materials and methods: This study investigated the immunoprofiles of PIAS? in 231 Nigerian BC prepared as tissue microarrays and correlated their protein expression with clinical outcome, pathological responses and the expression of 14 other relevant biomarkers.

Results: PIAS? protein expression showed a significant correlation with higher histological grade, basal-like biomarkers expression (CK14, CK5/6 and EGFR), BRCA1 regulator (MTA1), p53, PI3KCA, basal-like phenotype and TNBC. Also, an inverse correlation with steroid hormones (ER and PgR), p27, MDM4, mucin 1 and BRCA1 was observed with PIAS? expression. Univariate and multivariate survival analyses showed PIAS? expression was a predictor of poor outcome independent of tumour histological grade and ER expression.

Conclusions: PIAS? appears to be important in breast cancer behaviour arising from Nigerian women. PIAS? may therefore be useful for the screening of basal-like and TNBC. Also, development of novel therapies towards targeting PIAS? functional pathways may enhance the BC management among this ethnic nationality.


Agboola, A., Musa, A., Banjo, A., Ayoade, B., Deji-Agboola, M., Nolan, C., …Green, A. (2014). PIASγ expression in relation to clinicopathological, tumour factors and survival in indigenous black breast cancer women. Journal of Clinical Pathology, 67(4), 301-306.

Journal Article Type Article
Acceptance Date Sep 26, 2013
Online Publication Date Oct 29, 2013
Publication Date 2014-04
Deposit Date Oct 17, 2018
Journal Journal of Clinical Pathology
Print ISSN 0021-9746
Electronic ISSN 1472-4146
Publisher BMJ Publishing Group
Peer Reviewed Peer Reviewed
Volume 67
Issue 4
Pages 301-306
Public URL
Publisher URL