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Checkpoint kinase1 (CHK1) is an important biomarker in breast cancer having a role in chemotherapy response

Al-kaabi, M.M.; Alshareeda, A.T.; Jerjees, D.A.; Muftah, A.A.; Green, A.R.; Alsubhi, N.H.; Nolan, C.C.; Chan, S.; Cornford, E.; Madhusudan, S.; Ellis, I.O.; Rakha, E.A.

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Authors

M.M. Al-kaabi

A.T. Alshareeda

D.A. Jerjees

A.A. Muftah

N.H. Alsubhi

C.C. Nolan

S. Chan

E. Cornford

EMAD RAKHA Emad.Rakha@nottingham.ac.uk
Professor of Breast Cancer Pathology



Abstract

Background:

Checkpoint kinase1 (CHK1), which is a key component of DNA-damage-activated checkpoint signalling response, may have a role in breast cancer (BC) pathogenesis and influence response to chemotherapy. This study investigated the clinicopathological significance of phosphorylated CHK1 (pCHK1) protein in BC.
Method:

pCHK1 protein expression was assessed using immunohistochemistry in a large, well-characterized annotated series of early-stage primary operable invasive BC prepared as tissue microarray (n=1200).
Result:

pCHK1 showed nuclear and/or cytoplasmic expression. Tumours with nuclear expression showed positive associations with favourable prognostic features such as lower grade, lower mitotic activity, expression of hormone receptor and lack of expression of KI67 and PI3K (P

Citation

Al-kaabi, M., Alshareeda, A., Jerjees, D., Muftah, A., Green, A., Alsubhi, N., …Rakha, E. (2015). Checkpoint kinase1 (CHK1) is an important biomarker in breast cancer having a role in chemotherapy response. British Journal of Cancer, 112(5), 901-911. https://doi.org/10.1038/bjc.2014.576

Journal Article Type Article
Acceptance Date Sep 23, 2014
Online Publication Date Feb 17, 2015
Publication Date 2015-03
Deposit Date Oct 17, 2018
Publicly Available Date Oct 17, 2018
Journal British Journal of Cancer
Print ISSN 0007-0920
Electronic ISSN 1532-1827
Publisher Cancer Research UK
Peer Reviewed Peer Reviewed
Volume 112
Issue 5
Pages 901-911
DOI https://doi.org/10.1038/bjc.2014.576
Public URL https://nottingham-repository.worktribe.com/output/1171615
Publisher URL https://www.nature.com/articles/bjc2014576