ANDREW GREEN ANDREW.GREEN@NOTTINGHAM.AC.UK
Associate Professor
MYC functions are specific in biological subtypes of breast cancer and confers resistance to endocrine therapy in luminal tumours
Green, Andrew R.; Aleskandarany, Mohammed A.; Agarwal, Devika; Elsheikh, Somaia; Nolan, Christopher C.; Diez-Rodriguez, Maria; Macmillan, R. Douglas; Ball, Graham R.; Caldas, Carlos; Madhusudan, Srinivasan; Ellis, Ian O.; Rakha, Emad A.
Authors
Mohammed A. Aleskandarany
Devika Agarwal
Somaia Elsheikh
Christopher C. Nolan
Maria Diez-Rodriguez
R. Douglas Macmillan
Graham R. Ball
Carlos Caldas
SRINIVASAN MADHUSUDAN srinivasan.madhusudan@nottingham.ac.uk
Professor of Medical Oncology
Professor IAN ELLIS IAN.ELLIS@NOTTINGHAM.AC.UK
Professor of Cancer Pathology
EMAD RAKHA Emad.Rakha@nottingham.ac.uk
Professor of Breast Cancer Pathology
Abstract
Background:
MYC is amplified in approximately 15% of breast cancers (BCs) and is associated with poor outcome. c-MYC protein is multi-faceted and participates in many aspects of cellular function and is linked with therapeutic response in BCs. We hypothesised that the functional role of c-MYC differs between molecular subtypes of BCs.
Methods:
We therefore investigated the correlation between c-MYC protein expression and other proteins involved in different cellular functions together with clinicopathological parameters, patients’ outcome and treatments in a large early-stage molecularly characterised series of primary invasive BCs (n=1106) using immunuohistochemistry. The METABRIC BC cohort (n=1980) was evaluated for MYC mRNA expression and a systems biology approach utilised to identify genes associated with MYC in the different BC molecular subtypes.
Results:
High MYC and c-MYC expression was significantly associated with poor prognostic factors, including grade and basal-like BCs. In luminal A tumours, c-MYC was associated with ATM (P=0.005), Cyclin B1 (P=0.002), PIK3CA (P=0.009) and Ki67 (P
Citation
Green, A. R., Aleskandarany, M. A., Agarwal, D., Elsheikh, S., Nolan, C. C., Diez-Rodriguez, M., …Rakha, E. A. (2016). MYC functions are specific in biological subtypes of breast cancer and confers resistance to endocrine therapy in luminal tumours. British Journal of Cancer, 114(8), 917-928. https://doi.org/10.1038/bjc.2016.46
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 9, 2016 |
Online Publication Date | Mar 8, 2016 |
Publication Date | 2016-04 |
Deposit Date | Oct 16, 2018 |
Publicly Available Date | Oct 18, 2018 |
Journal | British Journal of Cancer |
Print ISSN | 0007-0920 |
Electronic ISSN | 1532-1827 |
Publisher | Cancer Research UK |
Peer Reviewed | Peer Reviewed |
Volume | 114 |
Issue | 8 |
Pages | 917-928 |
DOI | https://doi.org/10.1038/bjc.2016.46 |
Public URL | https://nottingham-repository.worktribe.com/output/1169998 |
Publisher URL | https://www.nature.com/articles/bjc201646 |
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