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Neuropsychological function at first episode in treatment-resistant psychosis: Findings from the ÆsOP-10 study

MacCabe, James H.; Kravariti, Eugenia; Demjaha, Arsime; Zanelli, Jolanta; Ibrahim, Fowzia; Wise, Catherine; Reichenberg, Abraham; Pilecka, Izabela; Morgan, Kevin; Fearon, Paul; Morgan, Craig; Doody, Gillian A.; Donoghue, Kim; Jones, Peter B.; Kaçar, Anil Şafak; Dazzan, Paola; Lappin, Julia; Murray, Robin M.


James H. MacCabe

Eugenia Kravariti

Arsime Demjaha

Jolanta Zanelli

Fowzia Ibrahim

Catherine Wise

Abraham Reichenberg

Izabela Pilecka

Kevin Morgan

Paul Fearon

Craig Morgan

Kim Donoghue

Peter B. Jones

Anil Şafak Kaçar

Paola Dazzan

Julia Lappin

Robin M. Murray


© Cambridge University Press 2018Â This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (, which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. © Cambridge University Press 2018. Background Neuropsychological investigations can help untangle the aetiological and phenomenological heterogeneity of schizophrenia but have scarcely been employed in the context of treatment-resistant (TR) schizophrenia. No population-based study has examined neuropsychological function in the first-episode of TR psychosis.Methods We report baseline neuropsychological findings from a longitudinal, population-based study of first-episode psychosis, which followed up cases from index admission to 10 years. At the 10-year follow up patients were classified as treatment responsive or TR after reconstructing their entire case histories. Of 145 cases with neuropsychological data at baseline, 113 were classified as treatment responsive, and 32 as TR at the 10-year follow-up.Results Compared with 257 community controls, both case groups showed baseline deficits in three composite neuropsychological scores, derived from principal component analysis: verbal intelligence and fluency, visuospatial ability and executive function, and verbal memory and learning (p valuesâ 0.001). Compared with treatment responders, TR cases showed deficits in verbal intelligence and fluency, both in the extended psychosis sample (t =-2.32; p = 0.022) and in the schizophrenia diagnostic subgroup (t =-2.49; p = 0.017). Similar relative deficits in the TR cases emerged in sub-/sensitivity analyses excluding patients with delayed-onset treatment resistance (p values


MacCabe, J. H., Kravariti, E., Demjaha, A., Zanelli, J., Ibrahim, F., Wise, C., …Murray, R. M. (2018). Neuropsychological function at first episode in treatment-resistant psychosis: Findings from the ÆsOP-10 study. Psychological Medicine, 49(12), 2100-2110.

Journal Article Type Article
Acceptance Date Sep 20, 2018
Online Publication Date Oct 23, 2018
Publication Date Oct 23, 2018
Deposit Date Oct 8, 2018
Publicly Available Date Oct 23, 2018
Journal Psychological Medicine
Print ISSN 0033-2917
Electronic ISSN 1469-8978
Publisher Cambridge University Press (CUP)
Peer Reviewed Peer Reviewed
Volume 49
Issue 12
Pages 2100-2110
Keywords Cohort study; population-based; psychosis; schizophrenia; first episode; treatment resistant; neuropsychological
Public URL
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