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Pathological validation and significance of micrometastasis in sentinel nodes in primary breast cancer

Rampaul, R.S.; Miremadi, A.; Pinder, S.E.; Lee, A.; Ellis, I.O.

Authors

R.S. Rampaul

A. Miremadi

S.E. Pinder

A. Lee

I.O. Ellis



Abstract

In embracing a multidisciplinary approach to the management of patients with sentinel node biopsy in breast cancer, the pathologist task is to screen sentinel nodes for possible metastasis. The consequences of missing sentinel node micrometastasis can directly influence treatment strategies, and this screening therefore has to be performed with more attention than usual. There is presently great diversity in the histopathological work-up of sentinel nodes, with many centres employing additional techniques such as immunohistochemistry, reverse transcription polymerase chain reaction or flow cytometry in addition to routine haematoxylin and eosin staining. In this review, we address the pathological validation and significance of micrometastasis in sentinel node biopsy in primary breast cancer

Citation

Rampaul, R., Miremadi, A., Pinder, S., Lee, A., & Ellis, I. (2001). Pathological validation and significance of micrometastasis in sentinel nodes in primary breast cancer. Breast Cancer Research, 3(2),

Journal Article Type Article
Publication Date Jan 1, 2001
Deposit Date Jul 30, 2004
Publicly Available Date Oct 9, 2007
Journal Breast Cancer Research
Print ISSN 1465-5411
Publisher Humana Press
Peer Reviewed Peer Reviewed
Volume 3
Issue 2
Public URL http://eprints.nottingham.ac.uk/id/eprint/125

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