Dendritic cable with active spines: a modeling study in the spike-diffuse-spike framework

Timofeeva, Yulia; Lord, Gabriel; Coombes, Stephen

Abstract

The spike-diffuse-spike (SDS) model describes a passive dendritic tree with active dendritic spines. Spine-head dynamics is modelled with a simple integrate-and-fire process, whilst communication between spines is mediated by the cable equation. Here we develop a computational framework that allows the study of multiple spiking events in a network of such spines embedded in a simple one-dimensional cable. This system is shown to support saltatory waves as a result of the discrete distribution of spines. Moreover, we demonstrate one of the ways to incorporate noise into the spine-head whilst retaining computational tractability of the model. The SDS model sustains a variety of propagating patterns.

Citation

Timofeeva, Y., Lord, G., & Coombes, S. Dendritic cable with active spines: a modeling study in the spike-diffuse-spike framework. https://doi.org/10.1016/j.neucom.2005.12.045

• Journal Article Type: Article
• Publication Date: Oct 1, 2005
• Deposit Date: Oct 24, 2005
• Publicly Available Date: Oct 9, 2007
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1016/j.neucom.2005.12.045
• Keywords: spike-diffuse-spike, dendritic spines, saltatory waves, noise
• Public URL: https://nottingham-repository.worktribe.com/output/1019914