DNA charge neutralisation by linear polymers II: reversible binding
Maltsev, Eugene; Wattis, Jonathan A.D.; Byrne, Helen M.
JONATHAN WATTIS firstname.lastname@example.org
Professor of Applied Mathematics
Helen M. Byrne
We model the way in which polymers bind to DNA and neutralise
its charged backbone by analysing the dynamics of the distribution
of gaps along the DNA.
We generalise existing theory for irreversible binding to construct
new deterministic models which include polymer removal,
movement along the DNA and allow for binding with overlaps.
We show that reversible binding alters the capacity of the DNA
for polymers by allowing the rearrangement of polymer positions
over a longer timescale than when binding is irreversible.
When the polymers do not overlap, allowing reversible binding
increases the number of polymers adhered and hence the charge that
the DNA can accommodate; in contrast, when overlaps occur, reversible
binding reduces the amount of charge neutralised by the polymers.
Maltsev, E., Wattis, J. A., & Byrne, H. M. DNA charge neutralisation by linear polymers II: reversible binding. Physical Review E, 74,
|Journal Article Type||Article|
|Deposit Date||Aug 15, 2008|
|Journal||Physical Review E|
|Publisher||American Physical Society|
|Peer Reviewed||Peer Reviewed|
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