Simon Garrett
Modelling Immunological Memory
Garrett, Simon; Robbins, Martin; Walker, Joanne; Wilson, William; Aickelin, Uwe
Authors
Martin Robbins
Joanne Walker
William Wilson
Uwe Aickelin
Contributors
D Flower
Editor
J Timmis
Editor
Abstract
Accurate immunological models offer the possibility of performing highthroughput experiments in silico that can predict, or at least suggest, in vivo phenomena. In this chapter, we compare various models of immunological memory. We first validate an experimental immunological simulator, developed by the authors, by simulating several theories of immunological memory with known results. We then use the same system to evaluate the predicted effects of a theory of immunological memory. The resulting model has not been explored before in artificial immune systems research, and we compare the simulated in silico output with in vivo measurements. Although the theory appears valid, we suggest that there are a common set of reasons why immunological memory models are a useful support tool; not conclusive in themselves.
Citation
Garrett, S., Robbins, M., Walker, J., Wilson, W., & Aickelin, U. Modelling Immunological Memory. In D. Flower, & J. Timmis (Eds.), Silico Immunology. Springer
Deposit Date | Oct 12, 2007 |
---|---|
Peer Reviewed | Peer Reviewed |
Volume | Chapte |
Book Title | Silico Immunology |
Public URL | https://nottingham-repository.worktribe.com/output/1018867 |
Files
06insilico_memory.pdf
(<nobr>2.2 Mb</nobr>)
PDF
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