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Modelling Immunological Memory

Garrett, Simon; Robbins, Martin; Walker, Joanne; Wilson, William; Aickelin, Uwe

Authors

Simon Garrett

Martin Robbins

Joanne Walker

William Wilson

Uwe Aickelin



Contributors

D Flower
Editor

J Timmis
Editor

Abstract

Accurate immunological models offer the possibility of performing highthroughput experiments in silico that can predict, or at least suggest, in vivo phenomena. In this chapter, we compare various models of immunological memory. We first validate an experimental immunological simulator, developed by the authors, by simulating several theories of immunological memory with known results. We then use the same system to evaluate the predicted effects of a theory of immunological memory. The resulting model has not been explored before in artificial immune systems research, and we compare the simulated in silico output with in vivo measurements. Although the theory appears valid, we suggest that there are a common set of reasons why immunological memory models are a useful support tool; not conclusive in themselves.

Citation

Garrett, S., Robbins, M., Walker, J., Wilson, W., & Aickelin, U. Modelling Immunological Memory. In D. Flower, & J. Timmis (Eds.), Silico ImmunologySpringer

Deposit Date Oct 12, 2007
Peer Reviewed Peer Reviewed
Volume Chapte
Book Title Silico Immunology
Public URL http://eprints.nottingham.ac.uk/id/eprint/585

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