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Spatio-temporal filtering properties of a dendritic cable with active spines: A modeling study in the spike-diffuse-spike framework

Timofeeva, Yulia; Lord, Gabriel; Coombes, Stephen


Yulia Timofeeva

Gabriel Lord


The spike-diffuse-spike (SDS) model describes a passive dendritic tree with active dendritic spines. Spine-head dynamics is modeled with a simple integrate-and-fire process, whilst communication between spines is mediated by the cable equation. In this paper we develop a computational framework that allows the study of multiple spiking events in a network of such spines embedded on a simple one-dimensional cable. In the first instance this system is shown to support saltatory waves with the same qualitative features as those observed in a model with Hodgkin-Huxley kinetics in the spine-head. Moreover, there is excellent agreement with the analytically calculated speed for a solitary saltatory pulse. Upon driving the system with time-varying external input we find that the distribution of spines can play a crucial role in determining spatio-temporal filtering properties. In particular, the SDS model in response to periodic pulse train shows a positive correlation between spine density and low-pass temporal filtering that is consistent with the experimental results of Rose and Fortune [1999, 'Mechanisms for generating temporal filters in the electrosensory system,' The Journal of Experimental Biology 202: 1281-1289]. Further, we demonstrate the robustness of observed wave properties to natural sources of noise that arise both in the cable and the spine-head, and highlight the possibility of purely noise induced waves and coherent oscillations. © Springer Science Business Media, LLC 2006.


Timofeeva, Y., Lord, G., & Coombes, S. (2006). Spatio-temporal filtering properties of a dendritic cable with active spines: A modeling study in the spike-diffuse-spike framework. Journal of Computational Neuroscience, 21(3), 293-306.

Journal Article Type Article
Acceptance Date Apr 12, 2006
Online Publication Date Jul 28, 2006
Publication Date Dec 1, 2006
Deposit Date Apr 7, 2006
Publicly Available Date Oct 9, 2007
Journal Journal of Computational Neuroscience
Print ISSN 0929-5313
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 21
Issue 3
Pages 293-306
Keywords spike-diffuse-spike, dendritic spines, filtering, noise
Public URL
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