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Parcellation of fMRI datasets with ICA and PLS: a data driven approach

Ji, Yongnan; Herv�, Pierre-Yves; Aickelin, Uwe; Pitiot, Alain

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Authors

Yongnan Ji

Pierre-Yves Herv�

Uwe Aickelin

Alain Pitiot



Contributors

Guang-Zhong Yang
Editor

Abstract

Inter-subject parcellation of functional Magnetic Resonance Imaging (fMRI) data based on a standard General Linear Model (GLM) and spectral clustering was recently proposed as a means to alleviate the issues associated with spatial normalization in fMRI. However, for all its appeal, a GLM-based parcellation approach introduces its own biases, in the form of a priori knowledge about the shape of Hemodynamic Response Function (HRF) and task-related signal changes, or about the subject behaviour during the task.

In this paper, we introduce a data-driven version of the spectral clustering parcellation, based on Independent Component Analysis (ICA) and Partial Least Squares (PLS) instead of the GLM. First, a number of independent components are automatically selected. Seed voxels are then obtained from the associated ICA maps and we compute the PLS latent variables between the fMRI signal of the seed voxels (which covers regional variations of the HRF) and the principal components of the signal across all voxels. Finally, we parcellate all subjects data with a spectral clustering of the PLS latent variables.

We present results of the application of the proposed method on both single-subject and multi-subject fMRI datasets. Preliminary experimental results, evaluated with intra-parcel variance of GLM t-values and PLS derived t-values, indicate that this data-driven approach offers improvement in terms of parcellation accuracy over GLM based techniques.

Citation

Ji, Y., Hervé, P.-Y., Aickelin, U., & Pitiot, A. (2009, September). Parcellation of fMRI datasets with ICA and PLS: a data driven approach. Presented at 12th International Conference, 2009, London, UK

Presentation Conference Type Edited Proceedings
Conference Name 12th International Conference, 2009
Start Date Sep 20, 2009
End Date Sep 24, 2009
Publication Date Sep 20, 2009
Deposit Date Aug 11, 2011
Publicly Available Date Aug 11, 2011
Publisher Springer
Peer Reviewed Peer Reviewed
Pages 984–991
Series Title Lecture notes in computer science
Series Number 5761
Series ISSN 1611-3349
Book Title Medical Image Computing and Computer-Assisted Intervention -- MICCAI 2009
ISBN 978-3-642-04267-6
DOI https://doi.org/10.1007/978-3-642-04268-3_121
Public URL https://nottingham-repository.worktribe.com/output/1014560
Publisher URL https://link.springer.com/chapter/10.1007/978-3-642-04268-3_121

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