Good laboratory practice: preventing introduction of bias at the bench

Macleod, Malcolm R.; Fisher, Marc; O'Collins, Victoria; Sena, Emily S.; Dirnagl, Ulrich; Bath, Philip M.W.; Buchan, Alistair; van der Worp, H. Bart; Traystman, Richard; Minematsu, Kazuo; Donnan, Geoffrey A.; Howells, David W.

Abstract

Background and Purpose—As a research community, we have failed to demonstrate that drugs which show substantial
efficacy in animal models of cerebral ischemia can also improve outcome in human stroke.

Summary of Review—Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct
and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective
efficacy.

Conclusions—Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal
experiments modeling human stroke.

Citation

Macleod, M. R., Fisher, M., O'Collins, V., Sena, E. S., Dirnagl, U., Bath, P. M., Buchan, A., van der Worp, H. B., Traystman, R., Minematsu, K., Donnan, G. A., & Howells, D. W. (2009). Good laboratory practice: preventing introduction of bias at the bench. Stroke, 40(3), Article e50-e52. https://doi.org/10.1161/strokeaha.108.525386

• Journal Article Type: Article
• Publication Date: Mar 1, 2009
• Deposit Date: Oct 28, 2009
• Publicly Available Date: Oct 28, 2009
• Journal: Stroke
• Print ISSN: 0039-2499
• Electronic ISSN: 1524-4628
• Publisher: American Heart Association
• Peer Reviewed: Peer Reviewed
• Volume: 40
• Issue: 3
• Article Number: e50-e52
• DOI: https://doi.org/10.1161/strokeaha.108.525386
• Public URL: https://nottingham-repository.worktribe.com/output/1013871
• Publisher URL: http://stroke.ahajournals.org/cgi/content/full/40/3/e50