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Relationship between hyperacute blood pressure and outcome after ischemic stroke: data from the VISTA Collaboration

Sare, Gillian M.; Ali, Myzoon; Shuaib, Ashfaq; Bath, Philip M.W.


Gillian M. Sare

Myzoon Ali

Ashfaq Shuaib

Philip M.W. Bath


Background and Purpose—High blood pressure (BP) is associated independently with poor outcome after acute ischemic stroke, although in most analyses “baseline” BP was measured 24 hours or more postictus, and not during the hyperacute period.
Methods—Analyses included 1722 patients in hyperacute trials (recruitment 8 hours) from the Virtual Stroke
International Stroke Trial Archive (VISTA) Collaboration. Data on BP at enrolment and after 1, 2, 16, 24, 48, and 72
hours, neurological impairment at 7 days (NIHSS), and functional outcome at 90 days (modified Rankin scale) were
assessed using logistic regression models, adjusted for confounding variables; results are for 10-mm Hg change in BP. Results—Mean time to enrolment was 3.7 hours (range 1.0 to 7.9). High systolic BP (SBP) was significantly associated
with increased neurological impairment (odds ratio, OR 1.06, 95% confidence interval, 95% CI 1.01 to 1.12), and poor functional outcome; odds ratios for both increased with later BP measurements made at up to 24 hours poststroke. Smaller (versus larger) declines in SBP over the first 24 hours were significantly associated with poor NIHSS scores (OR 1.16, 95% CI 1.05 to 1.27) and functional outcome (OR 1.23, 95% CI 1.13 to 1.34). A large variability in SBP was also associated with poor functional outcome.
Conclusions—High SBP and large variability in SBP in the hyperacute stages of ischemic stroke are associated with
increased neurological impairment and poor functional outcome, as are small falls in SBP over the first 24 hours.


Sare, G. M., Ali, M., Shuaib, A., & Bath, P. M. (2009). Relationship between hyperacute blood pressure and outcome after ischemic stroke: data from the VISTA Collaboration. Stroke, 40(6), doi:10.1161/STROKEAHA.108.539155

Journal Article Type Article
Publication Date Jun 1, 2009
Deposit Date Jun 17, 2010
Publicly Available Date Jun 17, 2010
Journal Stroke
Print ISSN 0039-2499
Electronic ISSN 1524-4628
Publisher American Heart Association
Peer Reviewed Peer Reviewed
Volume 40
Issue 6
Public URL
Publisher URL
Copyright Statement Copyright information regarding this work can be found at the following address:


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