Depolarization induced suppression of excitation and the emergence of ultraslow rhythms in neural networks

Hlinka, J.; Hlinka, Jaroslav; Coombes, S.

Abstract

Ultraslow fluctuations (0.01-0.1 Hz) are a feature of intrinsic brain activity of as yet unclear origin. We propose a candidate mechanism based on retrograde endocannabinoid signaling in a synaptically coupled network of excitatory neurons. This is known to cause depolarization-induced suppression of excitation (DISE), which we model phenomenologically. We construct emergent network oscillations in a globally coupled network and show that for strong synaptic coupling DISE can lead to a synchronized population burst at the frequencies of resting brain rhythms. © 2010 The American Physical Society.

Citation

Hlinka, J., Hlinka, J., & Coombes, S. (2010). Depolarization induced suppression of excitation and the emergence of ultraslow rhythms in neural networks. Physical Review Letters, 104(6), https://doi.org/10.1103/PhysRevLett.104.068101

• Journal Article Type: Article
• Acceptance Date: Jun 12, 2009
• Online Publication Date: Feb 8, 2010
• Publication Date: Feb 8, 2010
• Deposit Date: Jan 27, 2010
• Publicly Available Date: Feb 8, 2010
• Journal: Physical Review Letters
• Print ISSN: 0031-9007
• Electronic ISSN: 1079-7114
• Publisher: American Physical Society
• Peer Reviewed: Peer Reviewed
• Volume: 104
• Issue: 6
• DOI: https://doi.org/10.1103/PhysRevLett.104.068101
• Keywords: Neural networks, Depolarization induced suppression of excitation, splay states, Morris-Lecar model, strong global coupling
• Public URL: https://nottingham-repository.worktribe.com/output/1012772
• Publisher URL: https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.104.068101