Simulating the dynamics of T cell subsets throughout the lifetime

Foan, Stephanie; Jackson, Andrew M.; Spendlove, Ian; Aickelin, Uwe

Abstract

It is widely accepted that the immune system undergoes age-related changes correlating with increased disease in the elderly. T cell subsets have been implicated. The aim of this work is firstly to implement and validate a simulation
of T regulatory cell (Treg) dynamics throughout the lifetime, based on a model by Baltcheva. We show that our initial simulation produces an inversion between
precursor and mature Tregs at around 20 years of age, though the output differs significantly from the original laboratory dataset. Secondly, this report discusses
development of the model to incorporate new data from a cross-sectional study of healthy blood donors addressing balance between Tregs and Th17 cells with novel markers for Treg. The potential for simulation to add insight into immune aging is discussed.

Citation

Foan, S., Jackson, A. M., Spendlove, I., & Aickelin, U. (2011). Simulating the dynamics of T cell subsets throughout the lifetime. In P. Liò, G. Nicosia, & T. Stibor (Eds.), Artificial immune systems: 10th international conference, ICARIS 2011, Cambridge, UK, July 18-21, 2011: proceedings. Springer

• Publication Date: Jan 1, 2011
• Deposit Date: Jun 18, 2013
• Publicly Available Date: Jun 18, 2013
• Peer Reviewed: Peer Reviewed
• Issue: 6825
• Series Title: Lecture notes in computer science
• Book Title: Artificial immune systems: 10th international conference, ICARIS 2011, Cambridge, UK, July 18-21, 2011: proceedings
• ISBN: 9783642223716
• Public URL: https://nottingham-repository.worktribe.com/output/1010677
• Publisher URL: http://link.springer.com/chapter/10.1007/978-3-642-22371-6_8
• Additional Information: The final publication is available at link.springer.com