Cardiac cell modelling: observations from the heart of the cardiac physiome project

Fink, Martin; Niederer, Steven A.; Cherry, Elizabeth M.; Fenton, Flavio H.; Koivumäki, Jussi T.; Seemann, Gunnar; Thul, Ruediger; Zhang, Henggui; Sachse, Frank B.; Beard, Dan; Crampin, Edmund J.; Smith, Nicolas P.

Abstract

In this manuscript we review the state of cardiac cell modelling in the context of international initiatives such as the IUPS Physiome and Virtual Physiological Human Projects, which aim to integrate computational models across scales and physics. In particular we focus on the relationship between experimental data and model parameterisation across a range of model types and cellular physiological systems. Finally, in the context of parameter identification and model reuse within the Cardiac Physiome, we suggest some future priority areas for this field.

Citation

Fink, M., Niederer, S. A., Cherry, E. M., Fenton, F. H., Koivumäki, J. T., Seemann, G., …Smith, N. P. (2011). Cardiac cell modelling: observations from the heart of the cardiac physiome project. Progress in Biophysics and Molecular Biology, 104(1-3), doi:10.1016/j.pbiomolbio.2010.03.002

• Journal Article Type: Article
• Publication Date: Jan 1, 2011
• Deposit Date: Dec 21, 2012
• Publicly Available Date: Dec 21, 2012
• Journal: Progress in Biophysics and Molecular Biology
• Print ISSN: 0079-6107
• Electronic ISSN: 0079-6107
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 104
• Issue: 1-3
• DOI: https://doi.org/10.1016/j.pbiomolbio.2010.03.002
• Public URL: http://eprints.nottingham.ac.uk/id/eprint/1757
• Publisher URL: http://dx.doi.org/10.1016/j.pbiomolbio.2010.03.002
• Additional Information: NOTICE: this is the author’s version of a work that was accepted for publication in Progress in Biophysics and Molecular Biology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Progress in Biophysics and Molecular Biology, 104(1-3) (2011), doi: 10.1016/j.pbiomolbio.2010.03.002