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Cardiac cell modelling: observations from the heart of the cardiac physiome project

Fink, Martin; Niederer, Steven A.; Cherry, Elizabeth M.; Fenton, Flavio H.; Koivumäki, Jussi T.; Seemann, Gunnar; Thul, Ruediger; Zhang, Henggui; Sachse, Frank B.; Beard, Dan; Crampin, Edmund J.; Smith, Nicolas P.


Martin Fink

Steven A. Niederer

Elizabeth M. Cherry

Flavio H. Fenton

Jussi T. Koivumäki

Gunnar Seemann

Henggui Zhang

Frank B. Sachse

Dan Beard

Edmund J. Crampin

Nicolas P. Smith


In this manuscript we review the state of cardiac cell modelling in the context of international initiatives such as the IUPS Physiome and Virtual Physiological Human Projects, which aim to integrate computational models across scales and physics. In particular we focus on the relationship between experimental data and model parameterisation across a range of model types and cellular physiological systems. Finally, in the context of parameter identification and model reuse within the Cardiac Physiome, we suggest some future priority areas for this field.


Fink, M., Niederer, S. A., Cherry, E. M., Fenton, F. H., Koivumäki, J. T., Seemann, G., …Smith, N. P. (2011). Cardiac cell modelling: observations from the heart of the cardiac physiome project. Progress in Biophysics and Molecular Biology, 104(1-3), doi:10.1016/j.pbiomolbio.2010.03.002

Journal Article Type Article
Publication Date Jan 1, 2011
Deposit Date Dec 21, 2012
Publicly Available Date Dec 21, 2012
Journal Progress in Biophysics and Molecular Biology
Print ISSN 0079-6107
Electronic ISSN 0079-6107
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 104
Issue 1-3
Public URL
Publisher URL
Additional Information NOTICE: this is the author’s version of a work that was accepted for publication in Progress in Biophysics and Molecular Biology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Progress in Biophysics and Molecular Biology, 104(1-3) (2011), doi: 10.1016/j.pbiomolbio.2010.03.002


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