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Mathematical modeling of genome replication

Retkute, Renata; Nieduszynski, Conrad A.; Moura, Alessandro de

Authors

Renata Retkute

Conrad A. Nieduszynski

Alessandro de Moura



Abstract

Eukaryotic DNA replication is initiated from multiple sites on the chromosome, but little is known about the global and local regulation of replication. We present a mathematical model for the spatial dynamics of DNA replication, which offers insight into the kinetics of replication in different types of organisms. Most biological experiments involve average quantities over large cell populations (typically >107 cells) and therefore can mask the cell-to-cell variability present in the system. Although the model is formulated in terms of a population of cells, using mathematical analysis we show that one can obtain signatures of stochasticity in individual cells from averaged quantities. This work generalizes the result by Retkute et al. [Phys. Rev. Lett. 107, 068103 (2011)] to a broader set of parameter regimes.

Journal Article Type Article
Publication Date Jan 1, 2012
Journal Physical Review E
Print ISSN 2470-0045
Electronic ISSN 1539-3755
Publisher American Physical Society
Peer Reviewed Peer Reviewed
Volume 86
Article Number 031916
APA6 Citation Retkute, R., Nieduszynski, C. A., & Moura, A. D. (2012). Mathematical modeling of genome replication. Physical Review E, 86, doi:10.1103/PhysRevE.86.031916
DOI https://doi.org/10.1103/PhysRevE.86.031916
Publisher URL http://journals.aps.org/pre/abstract/10.1103/PhysRevE.86.031916
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0



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