Mathematical modeling of genome replication

Retkute, Renata; Nieduszynski, Conrad A.; Moura, Alessandro de

Abstract

Eukaryotic DNA replication is initiated from multiple sites on the chromosome, but little is known about the global and local regulation of replication. We present a mathematical model for the spatial dynamics of DNA replication, which offers insight into the kinetics of replication in different types of organisms. Most biological experiments involve average quantities over large cell populations (typically >107 cells) and therefore can mask the cell-to-cell variability present in the system. Although the model is formulated in terms of a population of cells, using mathematical analysis we show that one can obtain signatures of stochasticity in individual cells from averaged quantities. This work generalizes the result by Retkute et al. [Phys. Rev. Lett. 107, 068103 (2011)] to a broader set of parameter regimes.

Citation

Retkute, R., Nieduszynski, C. A., & Moura, A. D. (2012). Mathematical modeling of genome replication. Physical Review E, 86, Article 031916. https://doi.org/10.1103/PhysRevE.86.031916

• Journal Article Type: Article
• Publication Date: Jan 1, 2012
• Deposit Date: Apr 1, 2014
• Publicly Available Date: Apr 1, 2014
• Journal: Physical Review E
• Print ISSN: 2470-0045
• Electronic ISSN: 1539-3755
• Publisher: American Physical Society
• Peer Reviewed: Peer Reviewed
• Volume: 86
• Article Number: 031916
• DOI: https://doi.org/10.1103/PhysRevE.86.031916
• Public URL: https://nottingham-repository.worktribe.com/output/1009203
• Publisher URL: http://journals.aps.org/pre/abstract/10.1103/PhysRevE.86.031916