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Results of antibiotic susceptibility testing do not influence clinical outcome in children with cystic fibrosis

Hurley, M.N.; Amin Ariff, A.H.; Bertenshaw, C.; Bhatt, J.; Smyth, Alan R.

Authors

M.N. Hurley

A.H. Amin Ariff

C. Bertenshaw

J. Bhatt

Alan R. Smyth



Abstract

Introduction: Patients with CF experience pulmonary exacerbations. These are often initially empirically treated with intravenous antibiotics, with antibiotic choice refined after susceptibility testing.

Methods: We completed a 5-year retrospective review of children attending the Paediatric CF Unit, Nottingham. The respiratory sampling, antibiotic prescribing and susceptibility testing guidance were audited. Episodes were classified according to the concordance between the antibiotics prescribed and antibiotic susceptibility testing.

Results: Of 52 patients who had previously isolated Pseudomonas aeruginosa, 103 antibiotic courses were commenced that coincided with an isolation of P. aeruginosa. P. aeruginosa was fully susceptible, partially susceptible or fully resistant on 33%, 44.7% or 16.5% of occasions respectively. The antibiotic prescriptions were never changed following antibiotic susceptibility testing. We found no association between change in FEV1 (p = 0.54), change in BMI (p = 0.12) or time to next exacerbation (p = 0.66) and concordance between antibiotic susceptibility and the antibiotics administered.

Conclusion: This study contributes to mounting evidence questioning the utility of routine antibiotic susceptibility testing.

Citation

Hurley, M., Amin Ariff, A., Bertenshaw, C., Bhatt, J., & Smyth, A. R. (2012). Results of antibiotic susceptibility testing do not influence clinical outcome in children with cystic fibrosis. Journal of Cystic Fibrosis, 11(4), https://doi.org/10.1016/j.jcf.2012.02.006

Journal Article Type Article
Publication Date Jul 1, 2012
Deposit Date May 21, 2014
Publicly Available Date May 21, 2014
Journal Journal of Cystic Fibrosis
Print ISSN 1569-1993
Electronic ISSN 1873-5010
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 11
Issue 4
DOI https://doi.org/10.1016/j.jcf.2012.02.006
Keywords Cystic fibrosis, Antibiotic, Susceptibility testing, Pseudomonas
Public URL http://eprints.nottingham.ac.uk/id/eprint/3174
Publisher URL http://www.sciencedirect.com/science/article/pii/S156919931200015X

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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