Kin selection, quorum sensing and virulence in pathogenic bacteria

Rumbaugh, Kendra P.; Trivedi, Urvish; Watters, Chase; Burton-Chellew, Maxwell N.; Diggle, Stephen P.; West, Stuart A.

Abstract

Bacterial growth and virulence often depends upon the cooperative release of extracellular factors excreted in
response to quorum sensing (QS).We carried out an in vivo selection experiment in mice to examine how QS
evolves in response to variation in relatedness (strain diversity), and the consequences for virulence. We
started our experiment with two bacterial strains: a wild-type that both produces and responds to QS
signal molecules, and a lasR (signal-blind) mutant that does not release extracellular factors in response
to signal. We found that: (i) QS leads to greater growth within hosts; (ii) high relatedness favours the QS
wild-type; and (iii) low relatedness favours the lasR mutant. Relatedness matters in our experiment because,
at relatively low relatedness, the lasR mutant is able to exploit the extracellular factors produced by the cells
that respond to QS, and hence increase in frequency. Furthermore, our results suggest that because a higher
relatedness favours cooperative QS, and hence leads to higher growth, this will also lead to a higher virulence,
giving a relationship between relatedness and virulence that is in the opposite direction to that usually predicted
by virulence theory.

Citation

Rumbaugh, K. P., Trivedi, U., Watters, C., Burton-Chellew, M. N., Diggle, S. P., & West, S. A. (2012). Kin selection, quorum sensing and virulence in pathogenic bacteria. Proceedings of the Royal Society B: Biological Sciences, 279(1742), https://doi.org/10.1098/rspb.2012.0843

• Journal Article Type: Article
• Publication Date: Sep 1, 2012
• Deposit Date: Mar 28, 2014
• Publicly Available Date: Mar 28, 2014
• Journal: Proceedings of the Royal Society B: Biological Sciences
• Print ISSN: 0962-8452
• Electronic ISSN: 1471-2954
• Publisher: The Royal Society
• Peer Reviewed: Peer Reviewed
• Volume: 279
• Issue: 1742
• DOI: https://doi.org/10.1098/rspb.2012.0843
• Public URL: https://nottingham-repository.worktribe.com/output/1006763
• Publisher URL: http://rspb.royalsocietypublishing.org/content/279/1742/3584.abstract