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Specificity factors in cytoplasmic polyadenylation

Charlesworth, Amanda; Meijer, Hedda A.; de Moor, Cornelia H.

Authors

Amanda Charlesworth

Hedda A. Meijer

Cornelia H. de Moor



Abstract

Poly(A) tail elongation after export of an messenger RNA (mRNA) to the cytoplasm is called cytoplasmic polyadenylation. It was first discovered in oocytes and embryos, where it has roles in meiosis and development. In recent years, however, has been implicated in many other processes, including synaptic plasticity and mitosis. This review aims to introduce cytoplasmic polyadenylation with an emphasis on the factors and elements mediating this process for different mRNAs and in different animal species. We will discuss the RNA sequence elements mediating cytoplasmic polyadenylation in the 3′ untranslated regions of mRNAs, including the CPE, MBE, TCS, eCPE, and C-CPE. In addition to describing the role of general polyadenylation factors, we discuss the specific RNA binding protein families associated with cytoplasmic polyadenylation elements, including CPEB (CPEB1, CPEB2, CPEB3, and CPEB4), Pumilio (PUM2), Musashi (MSI1, MSI2), zygote arrest (ZAR2), ELAV like proteins (ELAVL1, HuR), poly(C) binding proteins (PCBP2, αCP2, hnRNP-E2), and Bicaudal C (BICC1). Some emerging themes in cytoplasmic polyadenylation will be highlighted. To facilitate understanding for those working in different organisms and fields, particularly those who are analyzing high throughput data, HUGO gene nomenclature for the human orthologs is used throughout. Where human orthologs have not been clearly identified, reference is made to protein families identified in man.

Citation

Charlesworth, A., Meijer, H. A., & de Moor, C. H. (2013). Specificity factors in cytoplasmic polyadenylation. Wiley Interdisciplinary Reviews: RNA, 4(4), doi:10.1002/wrna.1171

Journal Article Type Article
Publication Date Jul 1, 2013
Deposit Date Mar 31, 2014
Publicly Available Date Mar 31, 2014
Journal Wiley Interdisciplinary Reviews: RNA
Print ISSN 1757-7004
Electronic ISSN 1757-7004
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 4
Issue 4
DOI https://doi.org/10.1002/wrna.1171
Public URL http://eprints.nottingham.ac.uk/id/eprint/2526
Publisher URL http://onlinelibrary.wiley.com/doi/10.1002/wrna.1171/abstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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