Skip to main content

Research Repository

Advanced Search

Outputs (6)

Bioactive coatings on 3D printed scaffolds for bone regeneration: Use of Laponite® to deliver BMP-2 in an ovine femoral condyle defect model (2024)
Journal Article
Marshall, K. M., McLaren, J. S., Wojciechowski, J. P., Callens, S. J. P., Echalier, C., Kanczler, J. M., Rose, F. R. A. J., Stevens, M. M., Dawson, J. I., & Oreffo, R. O. C. (2024). Bioactive coatings on 3D printed scaffolds for bone regeneration: Use of Laponite® to deliver BMP-2 in an ovine femoral condyle defect model. Biomaterials Advances, 164, Article 213959. https://doi.org/10.1016/j.bioadv.2024.213959

Biomaterial-based approaches for bone regeneration seek to explore alternative strategies to repair non-healing fractures and critical-sized bone defects. Fracture non-union occurs due to a number of factors resulting in the formation of bone defects... Read More about Bioactive coatings on 3D printed scaffolds for bone regeneration: Use of Laponite® to deliver BMP-2 in an ovine femoral condyle defect model.

Sub-optimal paternal diet at the time of mating disrupts maternal adaptations to pregnancy in the late gestation mouse (2024)
Journal Article
Khoshkerdar, A., Eid, N., Batra, V., Baker, N., Holmes, N., Henson, S., Sang, F., Wright, V., McLaren, J., Shakesheff, K., Woad, K. J., Morgan, H. L., & Watkins, A. J. (2024). Sub-optimal paternal diet at the time of mating disrupts maternal adaptations to pregnancy in the late gestation mouse. Nutrients, 16(12), Article 1879. https://doi.org/10.3390/nu16121879

Pregnancy represents a stage during which maternal physiology and homeostatic regulation undergo dramatic change and adaptation. The fundamental purpose of these adaptations is to ensure the survival of her offspring through adequate nutrient provisi... Read More about Sub-optimal paternal diet at the time of mating disrupts maternal adaptations to pregnancy in the late gestation mouse.

Sustained adenosine release: Revealing its impact on osteogenic signalling pathways of human mesenchymal stromal cells (2024)
Journal Article
Hajiali, H., McLaren, J., Gonzalez-García, C., Abdelrazig, S., Kim, D.-H., Dalby, M. J., Salmerón-Sánchez, M., & Rose, F. R. (2024). Sustained adenosine release: Revealing its impact on osteogenic signalling pathways of human mesenchymal stromal cells. Engineered Regeneration, 5(2), 255-268. https://doi.org/10.1016/j.engreg.2024.04.002

Non-healing fractures, a global health concern arising from trauma, osteoporosis, and tumours, can lead to severe disabilities. Adenosine, integral to cellular energy metabolism, gains prominence in bone regeneration via adenosine A2B receptor activa... Read More about Sustained adenosine release: Revealing its impact on osteogenic signalling pathways of human mesenchymal stromal cells.

Functional performance of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold: a pre-clinical in vitro tribological study (2024)
Journal Article
Cowie, R. M., Macri-Pellizzeri, L., McLaren, J., Sanderson, W. J., Felfel, R. M., Scotchford, C. A., Scammell, B. E., Grant, D. M., Sottile, V., & Jennings, L. M. (2024). Functional performance of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold: a pre-clinical in vitro tribological study. Royal Society Open Science, 11(1), Article 230431. https://doi.org/10.1098/rsos.230431

Osteochondral grafts are used for repair of focal osteochondral lesions. Autologous grafts are the gold standard treatment; however, limited graft availability and donor site morbidity restrict use. Therefore, there is a clinical need for different g... Read More about Functional performance of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold: a pre-clinical in vitro tribological study.

RAPID INTRAOPERATIVE GENETIC AUGMENTATION OF AUTOGRAFTS FOR RECONSTRUCTIVE SURGERY OF SEVERE TRAUMA (2022)
Presentation / Conference Contribution
Dixon, J., Thi Mai, T., McLaren, J., Ollivere, B., Scammell, B., & Eltaher, H. RAPID INTRAOPERATIVE GENETIC AUGMENTATION OF AUTOGRAFTS FOR RECONSTRUCTIVE SURGERY OF SEVERE TRAUMA

Survivors with severe tissue injury have unmet clinical needs for better bone and soft tissue regeneration. Specifically they have progressive tissue loss due to inflammation, necrosis, infection and the development of critical size bone defects is a... Read More about RAPID INTRAOPERATIVE GENETIC AUGMENTATION OF AUTOGRAFTS FOR RECONSTRUCTIVE SURGERY OF SEVERE TRAUMA.