Association between serum urate and flares in people with gout and evidence for surrogate status: a secondary analysis of two randomised controlled trials
(2021)
Journal Article
Stamp, L. K., Frampton, C., Morillon, M. B., Taylor, W. J., Dalbeth, N., Singh, J. A., Doherty, M., Zhang, W., Richardson, H., Sarmanova, A., & Christensen, R. (2022). Association between serum urate and flares in people with gout and evidence for surrogate status: a secondary analysis of two randomised controlled trials. The Lancet Rheumatology, 4(1), e53-e60. https://doi.org/10.1016/s2665-9913%2821%2900319-2
Background
Use of serum urate as a treatment target and outcome measure has become controversial in view of the 2017 American College of Physicians guidelines, which advocated a treat-to-symptom rather than a treat-to-target serum urate approach to...
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