Outputs (5)

The rat osteoarthritis bone score for histological pathology relevant to human bone marrow lesions and pain (2024)
Journal Article
McWilliams, D. F., Shahtaheri, M., Koushesh, S., Joseph, C., Gowler, P. R., Xu, L., Chapman, V., Sofat, N., & Walsh, D. A. (2025). The rat osteoarthritis bone score for histological pathology relevant to human bone marrow lesions and pain. Osteoarthritis and Cartilage Open, 7(1), Article 100544. https://doi.org/10.1016/j.ocarto.2024.100544

Objectives
Histological osteochondral characteristics of inflammation, fibrosis, vascularity, cartilage islands, vessels entering cartilage, thickened trabeculae and cysts are associated with bone marrow lesions (BMLs) in human knee osteoarthritis (... Read More about The rat osteoarthritis bone score for histological pathology relevant to human bone marrow lesions and pain.

Contribution of inflammation markers and quantitative sensory testing (QST) indices of central sensitisation to rheumatoid arthritis pain (2024)
Journal Article
Georgopoulos, V., Smith, S., McWilliams, D. F., Ferguson, E., Wakefield, R., Platts, D., Ledbury, S., Wilson, D., & Walsh, D. A. (2024). Contribution of inflammation markers and quantitative sensory testing (QST) indices of central sensitisation to rheumatoid arthritis pain. Arthritis Research and Therapy, 26(1), Article 175. https://doi.org/10.1186/s13075-024-03407-5

Background: Pain, the primary complaint in rheumatoid arthritis (RA), is multifaceted, and may be driven by inflammatory disease activity and central sensitisation. We aimed to ascertain what proportion of RA pain severity is explained by markers of... Read More about Contribution of inflammation markers and quantitative sensory testing (QST) indices of central sensitisation to rheumatoid arthritis pain.

Validation of a questionnaire for central nervous system aspects of joint pain: the CAP questionnaire (2024)
Journal Article
McWilliams, D., Georgopoulos, V., Patel, J., Millar, B., Smith, S., & Walsh, D. (2024). Validation of a questionnaire for central nervous system aspects of joint pain: the CAP questionnaire. Rheumatology, 63(12), 3306-3314. https://doi.org/10.1093/rheumatology/keae342

Background

Neuropathic-like pain, fatigue, cognitive difficulty, catastrophizing, anxiety, sleep disturbance, depression and widespread pain associate with a single factor in people with knee pain. We report the Central Aspects of Pain questionnai... Read More about Validation of a questionnaire for central nervous system aspects of joint pain: the CAP questionnaire.

The rat Osteoarthritis Bone Score: a new histological system for scoring subchondral pathology in rat knees analogous to histological correlates of human OA bone marrow lesions (2024)
Presentation / Conference Contribution
McWilliams, D. F., Shahtaheri, M., Koushesh, S., Joseph, C., Gowler, P., Chapman, V., Sofat, N., & Walsh, D. A. The rat Osteoarthritis Bone Score: a new histological system for scoring subchondral pathology in rat knees analogous to histological correlates of human OA bone marrow lesions. Presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

Purpose (the aim of the study): Bone marrow lesions (BMLs) are detected by MRI in the in human osteoarthritis (OA) subchondral bone and associated with pain. We previously described 7 histological features associated with BMLs from which we developed... Read More about The rat Osteoarthritis Bone Score: a new histological system for scoring subchondral pathology in rat knees analogous to histological correlates of human OA bone marrow lesions.

The association of painful and non-painful morbidities with frailty: a cross sectional analysis of a cohort of community dwelling older people in England (2024)
Journal Article
Chaplin, W. J., Lewis, H. R., Shahtaheri, S. M., Millar, B. S., McWilliams, D. F., Gladman, J. R. F., & Walsh, D. A. (2024). The association of painful and non-painful morbidities with frailty: a cross sectional analysis of a cohort of community dwelling older people in England. BMC Geriatrics, 24, Article 158. https://doi.org/10.1186/s12877-023-04602-w

Introduction
The association between chronic pain and frailty might indicate that pain is an independent driver of frailty but might alternatively be explained by inclusion within frailty identification tools of morbidities that commonly lead to chr... Read More about The association of painful and non-painful morbidities with frailty: a cross sectional analysis of a cohort of community dwelling older people in England.