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ERS international congress, madrid, 2019: Highlights from the airway diseases, asthma and COPD assembly (2020)
Journal Article
Lahousse, L., Bahmer, T., Cuevas-Ocaña, S., Flajolet, P., Mathioudakis, A. G., McDonnell, M., Uller, L., Schleich, F., Junior, S. D., Idzko, M., Singh, D., Ricciardolo, F. L., Adcock, I. M., Usmani, O., Spanevello, A., & Bonvini, S. J. (2020). ERS international congress, madrid, 2019: Highlights from the airway diseases, asthma and COPD assembly. ERJ Open Research, 6(1), https://doi.org/10.1183/23120541.00341-2019

The European Respiratory Society (ERS) International Congress 2019 in Madrid, Spain, was a platform for scientific discussion of the highest quality scientific research, cutting-edge techniques and innovative new therapies within the respiratory fiel... Read More about ERS international congress, madrid, 2019: Highlights from the airway diseases, asthma and COPD assembly.

FibroScan-AST (FAST) score for the non-invasive identification of patients with non-alcoholic steatohepatitis with significant activity and fibrosis: a prospective derivation and global validation study (2020)
Journal Article
Newsome, P. N., Sasso, M., Deeks, J. J., Paredes, A., Boursier, J., Chan, W.-K., Yilmaz, Y., Czernichow, S., Zheng, M.-H., Wong, V. W.-S., Allison, M., Tsochatzis, E., Anstee, Q. M., Sheridan, D. A., Eddowes, P. J., Guha, I. N., Cobbold, J. F., Paradis, V., Bedossa, P., Miette, V., …Harrison, S. A. (2020). FibroScan-AST (FAST) score for the non-invasive identification of patients with non-alcoholic steatohepatitis with significant activity and fibrosis: a prospective derivation and global validation study. The Lancet Gastroenterology & Hepatology, 5(4), 362-373. https://doi.org/10.1016/S2468-1253%2819%2930383-8

Background
The burden of non-alcoholic fatty liver disease (NAFLD) is increasing globally, and a major priority is to identify patients with non-alcoholic steatohepatitis (NASH) who are at greater risk of progression to cirrhosis, and who will be ca... Read More about FibroScan-AST (FAST) score for the non-invasive identification of patients with non-alcoholic steatohepatitis with significant activity and fibrosis: a prospective derivation and global validation study.

How can gene-editing of human pluripotent stem cells help cystic fibrosis? (2019)
Presentation / Conference Contribution
Cuevas Ocana, S., Wong, A., Aushev, M., Ye Yang, J., Perkins, N., Bear, C., Rossant, J., & Gray, M. How can gene-editing of human pluripotent stem cells help cystic fibrosis?. Presented at ERS International Congress 2019, Madrid, Spain

Cystic fibrosis (CF) is a monogenic recessive disorder, affecting 70,000 people worldwide. CF is due to mutations in the CFTR gene, resulting in a defective protein that leads to symptoms in numerous organs, especially lungs. Despite recent advances,... Read More about How can gene-editing of human pluripotent stem cells help cystic fibrosis?.

Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study (2019)
Journal Article
Coupland, C. A., Hill, T., Dening, T., Morriss, R., Moore, M., & Hippisley-Cox, J. (2019). Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study. JAMA Internal Medicine, 179(8), 1084-1093. https://doi.org/10.1001/jamainternmed.2019.0677

IMPORTANCE Anticholinergic medicines have short-term cognitive adverse effects, but it
is uncertain whether long-term use of these drugs is associated with an increased risk of dementia.

OBJECTIVE To assess associations between anticholinergic dr... Read More about Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study.

Drug Development for Nonalcoholic Fatty Liver Disease: Landscape and Challenges (2019)
Journal Article
Thiagarajan, P., & Aithal, G. P. (2019). Drug Development for Nonalcoholic Fatty Liver Disease: Landscape and Challenges. Journal of Clinical and Experimental Hepatology, 9(4), 515-521. https://doi.org/10.1016/j.jceh.2019.03.002

Nonalcoholic fatty liver disease (NAFLD) is now the leading cause of chronic liver disease in industrialized economies. With no licensed treatment currently available, together with a growing prevalence that parallels global increases in obesity and... Read More about Drug Development for Nonalcoholic Fatty Liver Disease: Landscape and Challenges.

Refractoriness to rituximab-based therapy and elevated serum B2-microglobulin predict for inferior survival in marginal zone lymphoma (2019)
Journal Article
Sorigue, M., Bishton, M., Domingo-Domenech, E., McMillan, A., Prusila, R., García, O., Kuusisto, M., Condom, M., Tapia, G., Ribera, J.-M., Kuittinen, O., Fox, C. P., & Sancho, J.-M. (2019). Refractoriness to rituximab-based therapy and elevated serum B2-microglobulin predict for inferior survival in marginal zone lymphoma. Leukemia & Lymphoma, 60(10), 2524-2531. https://doi.org/10.1080/10428194.2019.1594212

Short responses to immunochemotherapy predict for an inferior OS in follicular lymphoma. We set out to determine whether this is also the case in marginal zone lymphoma. A group of 139 marginal zone lymphoma (MZL) patients treated with front-line imm... Read More about Refractoriness to rituximab-based therapy and elevated serum B2-microglobulin predict for inferior survival in marginal zone lymphoma.

Identification and prospective stability of electronic nose (eNose)-derived inflammatory phenotypes in patients with severe asthma. (2018)
Journal Article
Brinkman, P., Wagener, A. H., Hekking, P.-P., Bansal, A. T., Maitland-van der Zee, A.-H., Wang, Y., Weda, H., Knobel, H. H., Vink, T. J., Rattray, N. J., D'Amico, A., Pennazza, G., Santonico, M., Lefaudeux, D., De Meulder, B., Auffray, C., Bakke, P. S., Caruso, M., Chanez, P., Chung, K. F., …Study Group, U.-B. (2019). Identification and prospective stability of electronic nose (eNose)-derived inflammatory phenotypes in patients with severe asthma. Journal of Allergy and Clinical Immunology, 143(5), 1811-1820. https://doi.org/10.1016/j.jaci.2018.10.058

Background: Severe asthma is a heterogeneous condition, as shown by independent cluster analyses based on demographic, clinical, and inflammatory characteristics. A next step is to identify molecularly driven phenotypes using “omics” technologies. Mo... Read More about Identification and prospective stability of electronic nose (eNose)-derived inflammatory phenotypes in patients with severe asthma..

Surface Plasmon Resonance Imaging of Excitable Cells (2018)
Preprint / Working Paper
Howe, C. L., Webb, K. F., Abayzeed, S. A., Anderson, D. J., Denning, C., & Russell, N. A. Surface Plasmon Resonance Imaging of Excitable Cells

Surface plasmons are highly sensitive to refractive index variations adjacent to the surface. This sensitivity has been exploited successfully for chemical and biological assays. In these systems, a surface plasmon resonance (SPR)-based sensor detect... Read More about Surface Plasmon Resonance Imaging of Excitable Cells.