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Discovery of highly selective inhibitors of calmodulin-dependent kinases that restore insulin sensitivity in the diet-induced obese in vivo mouse model. (2020)
Journal Article
Fromont, C., Atzori, A., Kaur, D., Hashmi, L., Greco, G., Cabanillas, A., Nguyen, H. V., Jones, D. H., Garzón, M., Varela, A., Stevenson, B., Iacobini, G., Lenoir, M., Rajesh, S., Box, C., Kumar, J., Grant, P., Novitskaia, V., Morgan, J., Sorrell, F., …Butterworth, S. (2020). Discovery of highly selective inhibitors of calmodulin-dependent kinases that restore insulin sensitivity in the diet-induced obese in vivo mouse model. Journal of Medicinal Chemistry, 63(13), 6784–6801. https://doi.org/10.1021/acs.jmedchem.9b01803

Mass transport of lipopolysaccharide induced H₂O₂ detected by an intracellular carbon nanoelectrode sensor (2020)
Journal Article
Hicks, J., Silman, N. J., Jackson, S., Aylott, J., & Rawson, F. (2020). Mass transport of lipopolysaccharide induced H₂O₂ detected by an intracellular carbon nanoelectrode sensor. Bioelectrochemistry, 135, Article 107547. https://doi.org/10.1016/j.bioelechem.2020.107547

Hydrogen peroxide is a key component of the innate immune response, regulating how a cell responds to a bacterial threat; however, being transient in nature makes it extremely difficult to detect. We show the development of an improved biosensor capa... Read More about Mass transport of lipopolysaccharide induced H₂O₂ detected by an intracellular carbon nanoelectrode sensor.

Thrombocytosis helps to stratify risk of colorectal cancer in patients referred on a 2-week-wait pathway (2020)
Journal Article
Bailey, J. A., Hanbali, N., Premji, K., Bunce, J., Mashlab, S., Simpson, J. A., Humes, D. J., & Banerjea, A. (2020). Thrombocytosis helps to stratify risk of colorectal cancer in patients referred on a 2-week-wait pathway. International Journal of Colorectal Disease, 35(7), 1347-1350. https://doi.org/10.1007/s00384-020-03597-9

Purpose
Primary care studies suggest that thrombocytosis (platelet counts > 400 × 109/L) is associated with an increased risk of colorectal cancer (CRC). We aimed to establish whether this marker has significant stratification value in patients seen... Read More about Thrombocytosis helps to stratify risk of colorectal cancer in patients referred on a 2-week-wait pathway.

ERS international congress, madrid, 2019: Highlights from the airway diseases, asthma and COPD assembly (2020)
Journal Article
Lahousse, L., Bahmer, T., Cuevas-Ocaña, S., Flajolet, P., Mathioudakis, A. G., McDonnell, M., Uller, L., Schleich, F., Junior, S. D., Idzko, M., Singh, D., Ricciardolo, F. L., Adcock, I. M., Usmani, O., Spanevello, A., & Bonvini, S. J. (2020). ERS international congress, madrid, 2019: Highlights from the airway diseases, asthma and COPD assembly. ERJ Open Research, 6(1), https://doi.org/10.1183/23120541.00341-2019

The European Respiratory Society (ERS) International Congress 2019 in Madrid, Spain, was a platform for scientific discussion of the highest quality scientific research, cutting-edge techniques and innovative new therapies within the respiratory fiel... Read More about ERS international congress, madrid, 2019: Highlights from the airway diseases, asthma and COPD assembly.

FibroScan-AST (FAST) score for the non-invasive identification of patients with non-alcoholic steatohepatitis with significant activity and fibrosis: a prospective derivation and global validation study (2020)
Journal Article
Newsome, P. N., Sasso, M., Deeks, J. J., Paredes, A., Boursier, J., Chan, W.-K., Yilmaz, Y., Czernichow, S., Zheng, M.-H., Wong, V. W.-S., Allison, M., Tsochatzis, E., Anstee, Q. M., Sheridan, D. A., Eddowes, P. J., Guha, I. N., Cobbold, J. F., Paradis, V., Bedossa, P., Miette, V., …Harrison, S. A. (2020). FibroScan-AST (FAST) score for the non-invasive identification of patients with non-alcoholic steatohepatitis with significant activity and fibrosis: a prospective derivation and global validation study. The Lancet Gastroenterology & Hepatology, 5(4), 362-373. https://doi.org/10.1016/S2468-1253%2819%2930383-8

Background
The burden of non-alcoholic fatty liver disease (NAFLD) is increasing globally, and a major priority is to identify patients with non-alcoholic steatohepatitis (NASH) who are at greater risk of progression to cirrhosis, and who will be ca... Read More about FibroScan-AST (FAST) score for the non-invasive identification of patients with non-alcoholic steatohepatitis with significant activity and fibrosis: a prospective derivation and global validation study.

Genetic syndromes predisposing to paediatric brain tumours: the chicken or the egg? (2020)
Journal Article
Madni, M., & Dandapani, M. (2020). Genetic syndromes predisposing to paediatric brain tumours: the chicken or the egg?. Paediatrics and Child Health, 30(3), 98-101. https://doi.org/10.1016/j.paed.2019.12.003

ancer in childhood is a disorder of growth and development. Up to 10% of patients diagnosed with cancer during childhood have a known underlying genetic predisposition syndrome. Affected individuals usually have multisystem involvement from the under... Read More about Genetic syndromes predisposing to paediatric brain tumours: the chicken or the egg?.

How can gene-editing of human pluripotent stem cells help cystic fibrosis? (2019)
Presentation / Conference Contribution
Cuevas Ocana, S., Wong, A., Aushev, M., Ye Yang, J., Perkins, N., Bear, C., Rossant, J., & Gray, M. How can gene-editing of human pluripotent stem cells help cystic fibrosis?. Presented at ERS International Congress 2019, Madrid, Spain

Cystic fibrosis (CF) is a monogenic recessive disorder, affecting 70,000 people worldwide. CF is due to mutations in the CFTR gene, resulting in a defective protein that leads to symptoms in numerous organs, especially lungs. Despite recent advances,... Read More about How can gene-editing of human pluripotent stem cells help cystic fibrosis?.

PTH-114 The impact of IBD related fatigue on health-related quality of life: a literature review (2019)
Presentation / Conference Contribution
Radford, S., McGing, J., Czuber-Dochan, W., & W Moran, G. (2019, June). PTH-114 The impact of IBD related fatigue on health-related quality of life: a literature review. Poster presented at BSG Annual Meeting, Glasgow, UK

Introduction Fatigue is a frequently reported symptom of inflammatory bowel disease (IBD) by patients in active disease and in remission. Fatigue related to chronic conditions reduces health-related quality of life (HRQoL) but has not been systematic... Read More about PTH-114 The impact of IBD related fatigue on health-related quality of life: a literature review.