Discovery of highly selective inhibitors of calmodulin-dependent kinases that restore insulin sensitivity in the diet-induced obese in vivo mouse model.

Fromont, Christophe; Atzori, Alessio; Kaur, Divneet; Hashmi, Lubna; Greco, Graziella; Cabanillas, Alejandro; Nguyen, Huy Van; Jones, D. Heulyn; Garzón, Miguel; Varela, Ana; Stevenson, Brett; Iacobini, Greg; Lenoir, Marc; Rajesh, Sundaresan; Box, Clare; Kumar, Jitendra; Grant, Paige; Novitskaia, Vera; Morgan, Juliet; Sorrell, Fiona; Redondo, Clara; Kramer, Andreas; Harris, C. John; Leighton, Brendan; Vickers, Steven; Cheetham, Sharon; Kenyon, Colin; Grabowska, Anna M.; Overduin, Michael; Berditchevski, Fedor; Weston, Chris J; Knapp, Stefan; Fischer, Peter M.; Butterworth, Sam

doi:10.1021/acs.jmedchem.9b01803

Discovery of highly selective inhibitors of calmodulin-dependent kinases that restore insulin sensitivity in the diet-induced obese in vivo mouse model.

Fromont, Christophe; Atzori, Alessio; Kaur, Divneet; Hashmi, Lubna; Greco, Graziella; Cabanillas, Alejandro; Nguyen, Huy Van; Jones, D. Heulyn; Garzón, Miguel; Varela, Ana; Stevenson, Brett; Iacobini, Greg; Lenoir, Marc; Rajesh, Sundaresan; Box, Clare; Kumar, Jitendra; Grant, Paige; Novitskaia, Vera; Morgan, Juliet; Sorrell, Fiona; Redondo, Clara; Kramer, Andreas; Harris, C. John; Leighton, Brendan; Vickers, Steven; Cheetham, Sharon; Kenyon, Colin; Grabowska, Anna M.; Overduin, Michael; Berditchevski, Fedor; Weston, Chris J; Knapp, Stefan; Fischer, Peter M.; Butterworth, Sam

Authors

Christophe Fromont

Alessio Atzori

Divneet Kaur

Lubna Hashmi

Graziella Greco

Alejandro Cabanillas

Huy Van Nguyen

D. Heulyn Jones

Miguel Garzón

Ana Varela

Brett Stevenson

Greg Iacobini

Marc Lenoir

Sundaresan Rajesh

Clare Box

Jitendra Kumar

Paige Grant

Vera Novitskaia

Juliet Morgan

Fiona Sorrell

Clara Redondo

Andreas Kramer

C. John Harris

Brendan Leighton

Steven Vickers

Sharon Cheetham

Colin Kenyon

ANNA GRABOWSKA ANNA.GRABOWSKA@NOTTINGHAM.AC.UK
Professor of Cancer Microenvironment

Michael Overduin

Fedor Berditchevski

Chris J Weston

Stefan Knapp

Peter M. Fischer

Sam Butterworth

Journal Article Type	Article
Acceptance Date	May 20, 2020
Online Publication Date	May 20, 2020
Publication Date	May 20, 2020
Deposit Date	Jun 9, 2020
Publicly Available Date	May 26, 2023
Journal	Journal of Medicinal Chemistry
Print ISSN	0022-2623
Electronic ISSN	1520-4804
Publisher	American Chemical Society
Peer Reviewed	Peer Reviewed
Volume	63
Issue	13
Pages	6784–6801
DOI	https://doi.org/10.1021/acs.jmedchem.9b01803
Keywords	Molecular Medicine; Drug Discovery
Public URL	https://nottingham-repository.worktribe.com/output/4612372
Publisher URL	https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01803

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Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model (5.1 Mb)
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Discovery of highly selective inhibitors of calmodulin-dependent kinases that restore insulin sensitivity in the diet-induced obese in vivo mouse model.

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