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Discovery of highly selective inhibitors of calmodulin-dependent kinases that restore insulin sensitivity in the diet-induced obese in vivo mouse model.

Fromont, Christophe; Atzori, Alessio; Kaur, Divneet; Hashmi, Lubna; Greco, Graziella; Cabanillas, Alejandro; Nguyen, Huy Van; Jones, D. Heulyn; Garzón, Miguel; Varela, Ana; Stevenson, Brett; Iacobini, Greg; Lenoir, Marc; Rajesh, Sundaresan; Box, Clare; Kumar, Jitendra; Grant, Paige; Novitskaia, Vera; Morgan, Juliet; Sorrell, Fiona; Redondo, Clara; Kramer, Andreas; Harris, C. John; Leighton, Brendan; Vickers, Steven; Cheetham, Sharon; Kenyon, Colin; Grabowska, Anna M.; Overduin, Michael; Berditchevski, Fedor; Weston, Chris J; Knapp, Stefan; Fischer, Peter M.; Butterworth, Sam

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Authors

Christophe Fromont

Alessio Atzori

Divneet Kaur

Lubna Hashmi

Graziella Greco

Alejandro Cabanillas

Huy Van Nguyen

D. Heulyn Jones

Miguel Garzón

Ana Varela

Brett Stevenson

Greg Iacobini

Marc Lenoir

Sundaresan Rajesh

Clare Box

Jitendra Kumar

Paige Grant

Vera Novitskaia

Juliet Morgan

Fiona Sorrell

Clara Redondo

Andreas Kramer

C. John Harris

Brendan Leighton

Steven Vickers

Sharon Cheetham

Colin Kenyon

Anna M. Grabowska

Michael Overduin

Fedor Berditchevski

Chris J Weston

Stefan Knapp

Peter M. Fischer

Sam Butterworth



Citation

Fromont, C., Atzori, A., Kaur, D., Hashmi, L., Greco, G., Cabanillas, A., …Butterworth, S. (2020). Discovery of highly selective inhibitors of calmodulin-dependent kinases that restore insulin sensitivity in the diet-induced obese in vivo mouse model. Journal of Medicinal Chemistry, 63(13), 6784–6801. https://doi.org/10.1021/acs.jmedchem.9b01803

Journal Article Type Article
Acceptance Date May 20, 2020
Online Publication Date May 20, 2020
Publication Date May 20, 2020
Deposit Date Jun 9, 2020
Publicly Available Date May 26, 2023
Journal Journal of Medicinal Chemistry
Print ISSN 0022-2623
Electronic ISSN 1520-4804
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 63
Issue 13
Pages 6784–6801
DOI https://doi.org/10.1021/acs.jmedchem.9b01803
Keywords Molecular Medicine; Drug Discovery
Public URL https://nottingham-repository.worktribe.com/output/4612372
Publisher URL https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01803

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