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Association between glucagon-like peptide-1 receptor agonists use and change in alcohol consumption: a systematic review (2024)
Journal Article
Subhani, M., Dhanda, A., King, J. A., Warren, F. C., Creanor, S., Davies, M. J., Eldeghaidy, S., Bawden, S., Gowland, P. A., Bataller, R., Greenwood, J., Kaar, S., Bhala, N., & Aithal, G. P. (2024). Association between glucagon-like peptide-1 receptor agonists use and change in alcohol consumption: a systematic review. eClinicalMedicine, 78, Article 102920. https://doi.org/10.1016/j.eclinm.2024.102920

Background
Despite the availability of various pharmacological and behavioural interventions, alcohol-related mortality is rising. This systematic review aimed to critically evaluate the existing literature on the association between glucagon-like p... Read More about Association between glucagon-like peptide-1 receptor agonists use and change in alcohol consumption: a systematic review.

Cell division cycle 6 ​is an independent prognostic biomarker in breast cancer (2024)
Journal Article
Kariri, Y. A., Alsaleem, M., Alhatlani, B. Y., Al-Kawaz, A., Mongan, N. P., Green, A. R., & Rakha, E. A. (2024). Cell division cycle 6 ​is an independent prognostic biomarker in breast cancer. Pathology, https://doi.org/10.1016/j.pathol.2024.09.006

Cell division cycle 6 (CDC6) is a cell cycle protein involved in cell cycle control, DNA replication and cancer cell apoptosis. This study investigated the prognostic value of CDC6 in breast cancer (BC) utilising large well-characterised cohorts of e... Read More about Cell division cycle 6 ​is an independent prognostic biomarker in breast cancer.

Nepal Family Cohort study: a study protocol (2024)
Journal Article
Kurmi, O. P., Chaudhary, N., Delanerolle, G., Bolton, C. E., Pant, P. R., Regmi, P. R., Gautam, S., Satia, I., Simkhada, P., Kyrou, I., Sigdel, T. K., Hundley, V., Dali, P. R., Løkke, A., Lam, K. B. H., Bennett, D., Custovic, A., van Teijlingen, E., Gill, P., Randeva, H., & O'Byrne, P. (2024). Nepal Family Cohort study: a study protocol. BMJ Open, 14(11), Article e088896. https://doi.org/10.1136/bmjopen-2024-088896

INTRODUCTION: The Nepal Family Cohort study uses a life course epidemiological approach to collect comprehensive data on children's and their parents' environmental, behavioural and metabolic risk factors. These factors can affect the overall develop... Read More about Nepal Family Cohort study: a study protocol.

The role of mesenchymal cells in cholangiocarcinoma (2024)
Journal Article
Sueca-Comes, M., Rusu, E. C., Ashworth, J. C., Collier, P., Probert, C., Ritchie, A., Meakin, M., Mongan, N. P., Egbuniwe, I. U., Andersen, J. B., Bates, D. O., & Grabowska, A. M. (2024). The role of mesenchymal cells in cholangiocarcinoma. Disease Models and Mechanisms, 17(12), Article dmm050716. https://doi.org/10.1242/dmm.050716

The tumour microenvironment (TME) significantly influences tumour formation and progression through dynamic interactions. Cholangiocarcinoma (CCA), a highly desmoplastic tumour, lacks early diagnostic biomarkers and has limited effective treatments o... Read More about The role of mesenchymal cells in cholangiocarcinoma.

High α-SMA expression in the tumor stroma is associated with adverse clinical parameters in mismatch repair–proficient colorectal cancers only (2024)
Journal Article
Sculthorpe, D. J., Denton, A., Fadhil, W., Rusnita, D., Ilyas, M., & Mukherjee, A. (2024). High α-SMA expression in the tumor stroma is associated with adverse clinical parameters in mismatch repair–proficient colorectal cancers only. American Journal of Clinical Pathology, https://doi.org/10.1093/ajcp/aqae145

Objectives
As mismatch repair status confers differential prognosis in colorectal cancers, this study aimed to determine associations of α–smooth muscle actin (α-SMA) protein expression in mismatch repair–proficient (pMMR) and mismatch repair–defici... Read More about High α-SMA expression in the tumor stroma is associated with adverse clinical parameters in mismatch repair–proficient colorectal cancers only.

Macrophages and the microbiome in chronic obstructive pulmonary disease (2024)
Journal Article
Sandhu, K. K., Scott, A., Tatler, A. L., Belchamber, K. B., & Cox, M. J. (2024). Macrophages and the microbiome in chronic obstructive pulmonary disease. European Respiratory Review, 33(174), Article 240053. https://doi.org/10.1183/16000617.0053-2024

COPD is a heterogeneous disease of the lungs characterised by restricted airflow. Chronic inflammation and recurrent bacterial infections are known to be important driving factors in exacerbations of this disease. Despite a marked increase in the num... Read More about Macrophages and the microbiome in chronic obstructive pulmonary disease.

Wnt/GSK-3β mediates posttranslational modifications of FLYWCH1 to regulate intestinal epithelial function and tumorigenesis in the colon (2024)
Journal Article
Almozyan, S., Babaei-Jadidi, R., Aljohani, A., Youssefi, S., Dalleywater, W., Kadam, P., Spencer-Dene, B., Rakha, E., Ilyas, M., & Shams Nateri, A. (2024). Wnt/GSK-3β mediates posttranslational modifications of FLYWCH1 to regulate intestinal epithelial function and tumorigenesis in the colon. Cancer Communications, https://doi.org/10.1002/cac2.12625

Hydroxyacid Oxidase 1, a Glutamine Metabolism-Associated Protein, Predicts Poor Patient Outcome in Luminal Breast Cancer (2024)
Journal Article
Erkan, B., MacIntyre, S., Brown, C., Fakroun, A., Lashen, A. G., Mongan, N. P., Ellis, I. O., Rakha, E. A., & Green, A. R. (2024). Hydroxyacid Oxidase 1, a Glutamine Metabolism-Associated Protein, Predicts Poor Patient Outcome in Luminal Breast Cancer. International Journal of Molecular Sciences, 25(21), Article 11572. https://doi.org/10.3390/ijms252111572

Breast cancer (BC), which remains the most prevalent malignancy among women, is characterised by significant heterogeneity across its molecular subtypes. Oestrogen receptor-positive (ER+) (luminal) BC represents approximately 75% of cases, and despit... Read More about Hydroxyacid Oxidase 1, a Glutamine Metabolism-Associated Protein, Predicts Poor Patient Outcome in Luminal Breast Cancer.

Neurosurgical application of olaparib from a thermo-responsive paste potentiates DNA damage to prolong survival in malignant glioma (2024)
Journal Article
Serra, R., Smith, S. J., Rowlinson, J., Gorelick, N., Moloney, C., McCrorie, P., Veal, G. J., Berry, P., Chalmers, A. J., Suk, I., Shakesheff, K. M., Alexander, C., Grundy, R. G., Brem, H., Tyler, B. M., & Rahman, R. (2024). Neurosurgical application of olaparib from a thermo-responsive paste potentiates DNA damage to prolong survival in malignant glioma. British Journal of Cancer, 131, 1858-1868. https://doi.org/10.1038/s41416-024-02878-2

Background: There is increased pan-cancer specific interest in repurposing the poly adenosine diphosphate-ribose polymerase-1 (PARP-1) inhibitor, olaparib, for newly diagnosed or recurrent isocitrate dehydrogenase wild type glioblastoma. We explore w... Read More about Neurosurgical application of olaparib from a thermo-responsive paste potentiates DNA damage to prolong survival in malignant glioma.