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Outputs (519)

The importance of translational science within the respiratory field (2024)
Journal Article
Meiners, S., Reynaert, N. L., Matthaiou, A. M., Rajesh, R., Ahmed, E., Guillamat-Prats, R., …Cuevas-Ocaña, S. (2024). The importance of translational science within the respiratory field. Breathe, 20(1), Article 230183. https://doi.org/10.1183/20734735.0183-2023

The Translational Science Working Group at the European Respiratory Society (ERS) aims to bridge the gap between basic and clinical science by providing a platform where scientists, clinicians and experts in the respiratory field can actively shape t... Read More about The importance of translational science within the respiratory field.

National Unified Renal Translational Research Enterprise: Idiopathic Nephrotic Syndrome (NURTuRE-INS) study (2024)
Journal Article
Colby, E., Hayward, S., Benavente, M., Robertson, F., Bierzynska, A., Osborne, A., Parmesar, K., Afzal, M., Chapman, T., Ullah, F., Davies, E., Nation, M., Cook, W., Johnson, T., Andag, U., Radresa, O., Skroblin, P., Bayerlova, M., Unwin, R., Vuilleumier, N., …Saleem, M. A. (2024). National Unified Renal Translational Research Enterprise: Idiopathic Nephrotic Syndrome (NURTuRE-INS) study. Clinical Kidney Journal, 17(8), Article sfae096. https://doi.org/10.1093/ckj/sfae096

Background
Idiopathic Nephrotic Syndrome (INS) is a heterogenous disease and current classification is based on observational responses to therapies or kidney histology. The National Unified Renal Translational Research Enterprise (NURTuRE)-INS coho... Read More about National Unified Renal Translational Research Enterprise: Idiopathic Nephrotic Syndrome (NURTuRE-INS) study.

Pharmacological inhibition of RAS overcomes FLT3 inhibitor resistance in FLT3-ITD+ AML through AP-1 and RUNX1 (2024)
Journal Article
Coleman, D. J., Keane, P., Chin, P. S., Ames, L., Kellaway, S., Blair, H., …Bonifer, C. (2024). Pharmacological inhibition of RAS overcomes FLT3 inhibitor resistance in FLT3-ITD+ AML through AP-1 and RUNX1. iScience, 27(4), Article 109576. https://doi.org/10.1016/j.isci.2024.109576

AML is characterized by mutations in genes associated with growth regulation such as internal tandem duplications (ITD) in the receptor kinase FLT3. Inhibitors targeting FLT3 (FLT3i) are being used to treat patients with FLT3-ITD+ but most relapse an... Read More about Pharmacological inhibition of RAS overcomes FLT3 inhibitor resistance in FLT3-ITD+ AML through AP-1 and RUNX1.

Prospective study of change in skin autofluorescence over time and mortality in people receiving hemodialysis (2024)
Journal Article
Viramontes-Hörner, D., Selby, N. M., & Taal, M. W. (2024). Prospective study of change in skin autofluorescence over time and mortality in people receiving hemodialysis. Kidney International Reports, 9(7), 2110-2116. https://doi.org/10.1016/j.ekir.2024.03.020

Introduction: Elevated skin autofluorescence (SAF), a measure of tissue accumulation of advanced glycation end products (AGEs), is a strong predictor of all-cause and cardiovascular mortality in the hemodialysis population. However, prospective studi... Read More about Prospective study of change in skin autofluorescence over time and mortality in people receiving hemodialysis.

SnoRNAs in cardiovascular development, function, and disease (2024)
Journal Article
Chabronova, A., Holmes, T. L., Hoang, D. M., Denning, C., James, V., Smith, J. G. W., & Peffers, M. J. (2024). SnoRNAs in cardiovascular development, function, and disease. Trends in Molecular Medicine, 30(6), 562-578. https://doi.org/10.1016/j.molmed.2024.03.004

Small nucleolar RNAs (snoRNAs) are emerging as important regulators of cardiovascular (patho)biology. Several roles of snoRNAs have recently been identified in heart development and congenital heart diseases, as well as their dynamic regulation in hy... Read More about SnoRNAs in cardiovascular development, function, and disease.

Regional variation of COVID-19 admissions, acute kidney injury and mortality in England - a national observational study using administrative data (2024)
Journal Article
Kolhe, N. V., Fluck, R. J., & Taal, M. W. (in press). Regional variation of COVID-19 admissions, acute kidney injury and mortality in England - a national observational study using administrative data. BMC Infectious Diseases, 24(1), Article 346. https://doi.org/10.1186/s12879-024-09210-6

Background: This study explores regional variations in COVID-19 hospitalization rates, in-hospital mortality, and acute kidney injury (AKI) in England. We investigated the influence of population demographic characteristics, viral strain changes, and... Read More about Regional variation of COVID-19 admissions, acute kidney injury and mortality in England - a national observational study using administrative data.

A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes: a pilot study (2024)
Journal Article
Ng, C., Dellschaft, N. S., Hoad, C., Marciani, L., Spiller, R., Crooks, C., …Smyth, A. R. (2024). A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes: a pilot study. NIHR Open Research, 3, Article 65. https://doi.org/10.3310/nihropenres.13510.2

Background
People with cystic fibrosis (CF) can experience recurrent chest infections, pancreatic exocrine insufficiency and gastrointestinal symptoms. New cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs improve lung funct... Read More about A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes: a pilot study.

Substantial cost savings of ultrasound-based management over magnetic resonance imaging-based management in an inflammatory bowel disease service (2024)
Journal Article
Radford, S. J., Abdul-Aema, B., Tench, C., Leighton, P., Coad, J., & Moran, G. W. (2024). Substantial cost savings of ultrasound-based management over magnetic resonance imaging-based management in an inflammatory bowel disease service. Scandinavian Journal of Gastroenterology, 59(6), 683-689. https://doi.org/10.1080/00365521.2024.2330588

Background: Imaging is used to monitor disease activity in small bowel Crohn’s disease (CD). Magnetic Resonance Enterography is often employed as a first modality in the United Kingdom for assessment and monitoring; however, waiting times, cost, pati... Read More about Substantial cost savings of ultrasound-based management over magnetic resonance imaging-based management in an inflammatory bowel disease service.

An optimized short‐term steroid therapy for chronic drug‐induced liver injury: A prospective randomized clinical trial (2024)
Journal Article
Huang, A., Zhu, Y., Liu, S., Sun, Y., Liu, Z., Liang, Q., Zhao, J., Chang, B., Bi, J., Liu, J., Zhai, X., Xie, H., Li, N., Tian, H., Han, L., Zhuang, Y., Ma, H., Teng, G., Zhang, W., Aithal, G. P., …Zou, Z. (2024). An optimized short‐term steroid therapy for chronic drug‐induced liver injury: A prospective randomized clinical trial. Liver International, 44(6), 1435-1447. https://doi.org/10.1111/liv.15899

Background and Aims
The use of corticosteroids in chronic drug-induced liver injury (DILI) is an important issue. Our previous randomized controlled trial showed that patients with chronic DILI benefited from a 48-week steroid stepwise reduction (SS... Read More about An optimized short‐term steroid therapy for chronic drug‐induced liver injury: A prospective randomized clinical trial.