Outputs (14)

Oncologists’ Perspectives on Ketogenic Diets in Pediatric Brain Cancer: Potential, Challenges, and the Path Forward (2025)
Journal Article
AlMutairi, H., Dandapani, M., Siddiqui, K., & McCullough, F. (in press). Oncologists’ Perspectives on Ketogenic Diets in Pediatric Brain Cancer: Potential, Challenges, and the Path Forward. Nutrients, 17(17), Article 2843. https://doi.org/10.3390/nu17172843

Background/objectives: Treating pediatric brain tumors remains challenging due to the limitations of conventional therapies, which often damage healthy cells. Ketogenic diets (KDs)—high in fat and low in carbohydrates—have emerged as potential adjunc... Read More about Oncologists’ Perspectives on Ketogenic Diets in Pediatric Brain Cancer: Potential, Challenges, and the Path Forward.

Global consensus from the PHITT consortium surrounding an interim chemotherapy guidance for the treatment of children with hepatoblastoma, hepatocellular neoplasm – not otherwise specified (HCN-NOS), hepatocellular carcinoma and fibrolamellar carcinoma after trial closure (2025)
Journal Article
Schmid, I., O'Neill, A. F., Watanabe, K., Aerts, I., Branchereau, S., Brock, P. R., Dandapani, M., Fresneau, B., Geller, J., Hishiki, T., Ingham, D., Kraal, K., Ronghe, M., Tiao, G., Trobaugh-Lotrario, A., Rangaswami, A., Sullivan, M. J., Zsiros, J., Hiyama, E., Malogolowkin, M., & Ansari, M. (2025). Global consensus from the PHITT consortium surrounding an interim chemotherapy guidance for the treatment of children with hepatoblastoma, hepatocellular neoplasm – not otherwise specified (HCN-NOS), hepatocellular carcinoma and fibrolamellar carcinoma after trial closure. EJC Paediatric Oncology, 5, Article 100235. https://doi.org/10.1016/j.ejcped.2025.100235

Malignant liver tumors affecting children and adolescents are rare. In order to adequately study liver tumors occurring in this patient population and establish a more uniform approach to therapy, the three primary liver tumor consortia, SIOPEL (main... Read More about Global consensus from the PHITT consortium surrounding an interim chemotherapy guidance for the treatment of children with hepatoblastoma, hepatocellular neoplasm – not otherwise specified (HCN-NOS), hepatocellular carcinoma and fibrolamellar carcinoma after trial closure.

Safety, Feasibility, and Effectiveness of Ketogenic Diet in Pediatric Patients With Brain Tumors: A Systematic Review (2025)
Journal Article
AlMutairi, H., Mccullough, F., Siddiqui, K., Ghemlas, I., AlHarbi, M., Grundy, R., & Dandapani, M. (2025). Safety, Feasibility, and Effectiveness of Ketogenic Diet in Pediatric Patients With Brain Tumors: A Systematic Review. Journal of Nutrition and Metabolism, https://doi.org/10.1155/jnme/7935879

Background: Evidence suggests the positive effects of ketogenic diet (KD) on cancers by limiting glucose availability to cancer cells. This systematic review aimed to explore the safety, feasibility, and effectiveness of KD in children with brain tum... Read More about Safety, Feasibility, and Effectiveness of Ketogenic Diet in Pediatric Patients With Brain Tumors: A Systematic Review.

Monitoring central nervous system tumour metabolism using cerebrospinal fluid (2024)
Journal Article
Whitby, A., & Dandapani, M. (2024). Monitoring central nervous system tumour metabolism using cerebrospinal fluid. Frontiers in Oncology, 14, Article 1389529. https://doi.org/10.3389/fonc.2024.1389529

Central nervous system (CNS) tumours are the most common cancer cause of death in under 40s in the UK, largely because they persist and recur and sometimes metastasise during treatment. Therefore, longitudinal monitoring of patients during and follow... Read More about Monitoring central nervous system tumour metabolism using cerebrospinal fluid.

Evaluation of Pathway to Diagnosis of Pediatric Brain Tumors in Tamil Nadu, India (2024)
Journal Article
Kartik, P., Liu, J.-F., Sudarsan, R. T., Srinivasan, A., Jayaraman, D., Sivaprakasam, P., John, R., Uppuluri, R., Scott, J. X., Jalali, R., & Dandapani, M. (2024). Evaluation of Pathway to Diagnosis of Pediatric Brain Tumors in Tamil Nadu, India. JCO Global Oncology, 10(10), Article e2300214. https://doi.org/10.1200/go.23.00214

Purpose
Delayed diagnosis and poor awareness are significant barriers to the early intervention of pediatric brain tumors. This multicenter observational study aimed to evaluate the baseline routes and time to diagnosis for pediatric brain tumors in... Read More about Evaluation of Pathway to Diagnosis of Pediatric Brain Tumors in Tamil Nadu, India.

The effectiveness and safety of proton beam radiation therapy in children and young adults with Central Nervous System (CNS) tumours: a systematic review (2024)
Journal Article
Wilson, J. S., Main, C., Thorp, N., Taylor, R. E., Majothi, S., Kearns, P. R., English, M., Dandapani, M., Phillips, R., Wheatley, K., & Pizer, B. (2024). The effectiveness and safety of proton beam radiation therapy in children and young adults with Central Nervous System (CNS) tumours: a systematic review. Journal of Neuro-Oncology, 167(1), 1-34. https://doi.org/10.1007/s11060-023-04510-4

Background
Central nervous system (CNS) tumours account for around 25% of childhood neoplasms. With multi-modal therapy, 5-year survival is at around 75% in the UK. Conventional photon radiotherapy has made significant contributions to survival, but... Read More about The effectiveness and safety of proton beam radiation therapy in children and young adults with Central Nervous System (CNS) tumours: a systematic review.

Understanding recent advances in genomic testing in paediatric oncology (2023)
Journal Article
Robinson, S. L., Seneviratne, N., & Dandapani, M. (2024). Understanding recent advances in genomic testing in paediatric oncology. Paediatrics and Child Health, 34(2), 43-48. https://doi.org/10.1016/j.paed.2023.11.001

Advancements in genomics have had a significant impact on our ability to diagnose and treat several health conditions, notably cancer. In this article, we discuss the evolution of genomic methods from the early first-generation genome sequencing meth... Read More about Understanding recent advances in genomic testing in paediatric oncology.

Characterisation of Aberrant Metabolic Pathways in Hepatoblastoma Using Liquid Chromatography and Tandem Mass Spectrometry (LC-MS/MS) (2023)
Journal Article
Whitby, A., Pabla, P., Shastri, B., Amugi, L., Del Río-Álvarez, Á., Kim, D.-H., Royo, L., Armengol, C., & Dandapani, M. (2023). Characterisation of Aberrant Metabolic Pathways in Hepatoblastoma Using Liquid Chromatography and Tandem Mass Spectrometry (LC-MS/MS). Cancers, 15(21), Article 5182. https://doi.org/10.3390/cancers15215182

Hepatoblastoma (HB) is a rare childhood tumour with an evolving molecular landscape. We present the first comprehensive metabolomic analysis using untargeted and targeted liquid chromatography coupled to high-resolution tandem mass spectrometry (LC-M... Read More about Characterisation of Aberrant Metabolic Pathways in Hepatoblastoma Using Liquid Chromatography and Tandem Mass Spectrometry (LC-MS/MS).

Development of cancer surveillance guidelines in ataxia telangiectasia: A Delphi‐based consensus survey of international experts (2023)
Journal Article
Neves, R., DeDiosPerez, B., Panek, R., Jagani, S., Wilne, S., Mahendra Bhatt, J., Caputi, C., Cirillo, E., Coman, D. J., Dückers, G., Gilbert, D. L., Koenig, M. K., Mansour, L., McDermott, E., Pauni, M., Pignata, C., Perlman, S. L., Porras, O., Porto, M. B., Schon, K., …Dineen, R. A. (2023). Development of cancer surveillance guidelines in ataxia telangiectasia: A Delphi‐based consensus survey of international experts. Cancer Medicine, 12(13), 14663-14673. https://doi.org/10.1002/cam4.6075

Background/Objectives: Ataxia telangiectasia (A‐T) is a multiorgan disorder with increased vulnerability to cancer. Despite this increased cancer risk, there are no widely accepted guidelines for cancer surveillance in people affected by A‐T. We aime... Read More about Development of cancer surveillance guidelines in ataxia telangiectasia: A Delphi‐based consensus survey of international experts.

Evaluating the efficacy and safety of single-agent etoposide intra-CSF chemotherapy in children and young people with relapsed/refractory central nervous system tumours (2023)
Journal Article
Butler, A., Meijer, L., Liu, J.-F., Chohan, M., Jalloh, I., Macarthur, D., Parr, M., Wilne, S., Wilson, S., Walker, D., Grundy, R., & Dandapani, M. (2023). Evaluating the efficacy and safety of single-agent etoposide intra-CSF chemotherapy in children and young people with relapsed/refractory central nervous system tumours. Child's Nervous System, 39, 1537-1544. https://doi.org/10.1007/s00381-023-05872-w

Purpose
The aim of the project was to evaluate intra-CSF etoposide administration in a palliative setting for children and young people with relapsed/refractory central nervous system (CNS) tumours, with the primary endpoints being overall survival... Read More about Evaluating the efficacy and safety of single-agent etoposide intra-CSF chemotherapy in children and young people with relapsed/refractory central nervous system tumours.