Skip to main content

Research Repository

Advanced Search

Outputs (170)

Brain Connectome Graphs based Machine Learning for Diagnosis of Alzheimer’s Disease (2024)
Journal Article
Chen, K., Weng, Y., Dening, T., Hosseini, A. A., & Zuo, G. (2024). Brain Connectome Graphs based Machine Learning for Diagnosis of Alzheimer’s Disease. Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 20(S1), Article e090237. https://doi.org/10.1002/alz.090237

Background

Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline and memory loss. Early and accurate diagnosis of AD is crucial for patient information, advance planning, and potentially effective... Read More about Brain Connectome Graphs based Machine Learning for Diagnosis of Alzheimer’s Disease.

Magnetic Resonance Imaging of Inner Ear and Internal Auditory Canal Structures in the presence of a Cochlear Implant (2024)
Journal Article
Dewey, R. S., Dineen, R. A., Clemence, M., Menon, N., Bowtell, R., Boyle, P., & Hartley, D. E. H. (in press). Magnetic Resonance Imaging of Inner Ear and Internal Auditory Canal Structures in the presence of a Cochlear Implant. Otology and Neurotology,

Objective:

To determine whether the internal auditory canal (IAC) can be visualised using magnetic resonance imaging (MRI) in users of a cochlear implant (CI) model that can safely undergo MRI at 3T.

Patients:

Four normally-hearing contro... Read More about Magnetic Resonance Imaging of Inner Ear and Internal Auditory Canal Structures in the presence of a Cochlear Implant.

Exploring the Impact of Different Approaches to Healthcare Support for Older Care Home Residents in Greater Manchester on Ambulance Services and Unplanned Hospital Admissions (2024)
Journal Article
Hargreaves, C., Tucker, S., Hughes, J., Hothersall, G., Patterson, M., Gillan, V., & Challis, D. (2024). Exploring the Impact of Different Approaches to Healthcare Support for Older Care Home Residents in Greater Manchester on Ambulance Services and Unplanned Hospital Admissions. Journal of Long-Term Care, 2024, 489-499. https://doi.org/10.31389/jltc.339

Context:

Meeting the healthcare needs of care home residents is an international concern. In England, three approaches to enhance usual care provided by primary care general practitioners have been identified: additional direct (face-to-face) sup... Read More about Exploring the Impact of Different Approaches to Healthcare Support for Older Care Home Residents in Greater Manchester on Ambulance Services and Unplanned Hospital Admissions.

Specialist clinical pathways in audiology services for adults living with coexisting hearing loss and dementia: a scoping review protocol (2024)
Journal Article
Wenje, S. M., Calvert, S., Henshaw, H., Spriggs, R. V., Dening, T., Hendron, E., & Heffernan, E. (2024). Specialist clinical pathways in audiology services for adults living with coexisting hearing loss and dementia: a scoping review protocol. BMJ Open, 14(12), Article e087418. https://doi.org/10.1136/bmjopen-2024-087418

Introduction Both hearing loss and dementia are associated with ageing, and it is thought that many individuals living with dementia also live with hearing loss. Despite the large comorbidity between these two disorders, there remains a clear lack of... Read More about Specialist clinical pathways in audiology services for adults living with coexisting hearing loss and dementia: a scoping review protocol.

Developing treatments for cerebral small vessel disease: a scoping review of licensed interventions for potential repurposing (2024)
Journal Article
M Bath, P., P Phan, E., Clay, G., Dawson, J., Malhotra, P., Howard, R., Pal, S., M Wardlaw, J., Quinn, T., & Macleod, M. (2024). Developing treatments for cerebral small vessel disease: a scoping review of licensed interventions for potential repurposing. F1000Research, 13, Article 1546. https://doi.org/10.12688/f1000research.157890.1

Background
Cerebral small vessel disease (cSVD) is a progressive neurovascular-degenerative condition without specific treatment that causes lacunar stroke, most intracerebral haemorrhage, vascular cognitive impairment (VCI) and several neuropsychia... Read More about Developing treatments for cerebral small vessel disease: a scoping review of licensed interventions for potential repurposing.

Dual Antiplatelet Treatment up to 72 Hours After Ischemic Stroke Stratified by Risk Profile: A Post Hoc Analysis (2024)
Journal Article
Zhang, Y., Wang, X., Gao, Y., Chen, W., Johnston, S. C., Amarenco, P., Bath, P. M., Yan, H., Wang, T., Yang, Y., Zhou, Q., Wang, M., Jing, J., Wang, C., Wang, Y., Wang, Y., & Pan, Y. (2025). Dual Antiplatelet Treatment up to 72 Hours After Ischemic Stroke Stratified by Risk Profile: A Post Hoc Analysis. Stroke, 56(1), 46-55. https://doi.org/10.1161/strokeaha.124.049246

BACKGROUND: Risk profile of recurrence may influence the effect of antiplatelet therapy. This study aimed to evaluate the efficacy and safety of clopidogrel-aspirin initiated within 72 hours after symptom onset for acute mild stroke or high-risk tran... Read More about Dual Antiplatelet Treatment up to 72 Hours After Ischemic Stroke Stratified by Risk Profile: A Post Hoc Analysis.

One Year of Gluten-Free Diet Impacts Gut Function and Microbiome in Celiac Disease (2024)
Journal Article
Costigan, C. M., Warren, F. J., Duncan, A. P., Hoad, C. L., Lewis, N., Hill, T., Crooks, C. J., Morgan, P. S., Ciacci, C., Iovino, P., Sanders, D. S., Hildebrand, F., Gowland, P. A., Spiller, R. C., & Marciani, L. (2024). One Year of Gluten-Free Diet Impacts Gut Function and Microbiome in Celiac Disease. Clinical Gastroenterology and Hepatology, https://doi.org/10.1016/j.cgh.2024.11.006

Background & Aims: Currently, the main treatment for celiac disease (CD) is the gluten-free diet (GFD). This observational cohort study investigated the impact of CD and 1 year of GFD on gut function and microbiome. Methods: A total of 36 newly diagn... Read More about One Year of Gluten-Free Diet Impacts Gut Function and Microbiome in Celiac Disease.

A multi-view learning approach with diffusion model to synthesize FDG PET from MRI T1WI for diagnosis of Alzheimer's disease (2024)
Journal Article
Chen, K., Weng, Y., Huang, Y., Zhang, Y., Dening, T., Hosseini, A. A., & Xiao, W. (2024). A multi-view learning approach with diffusion model to synthesize FDG PET from MRI T1WI for diagnosis of Alzheimer's disease. Alzheimer's & Dementia: The Journal of the Alzheimer's Association, https://doi.org/10.1002/alz.14421

INTRODUCTION

This study presents a novel multi-view learning approach for machine learning (ML)–based Alzheimer's disease (AD) diagnosis.

METHODS

A diffusion model is proposed to synthesize the fluorodeoxyglucose positron emission tomography... Read More about A multi-view learning approach with diffusion model to synthesize FDG PET from MRI T1WI for diagnosis of Alzheimer's disease.

Whole brain functional connectivity: Insights from next generation neural mass modelling incorporating electrical synapses (2024)
Journal Article
Forrester, M., Petros, S., Cattell, O., Lai, Y. M., ODea, R. D., Sotiropoulos, S., & Coombes, S. (2024). Whole brain functional connectivity: Insights from next generation neural mass modelling incorporating electrical synapses. PLoS Computational Biology, 20(December), https://doi.org/10.1371/journal.pcbi.1012647

The ready availability of brain connectome data has both inspired and facilitated the modelling of whole brain activity using networks of phenomenological neural mass models that can incorporate both interaction strength and tract length between brai... Read More about Whole brain functional connectivity: Insights from next generation neural mass modelling incorporating electrical synapses.