Outputs (382)

Recommendations for quantitative cerebral perfusion MRI using multi‐timepoint arterial spin labeling: Acquisition, quantification, and clinical applications (2024)
Journal Article
Woods, J. G., Achten, E., Asllani, I., Bolar, D. S., Dai, W., Detre, J. A., …the ISMRM Perfusion Study Group. (2024). Recommendations for quantitative cerebral perfusion MRI using multi‐timepoint arterial spin labeling: Acquisition, quantification, and clinical applications. Magnetic Resonance in Medicine, 92(2), 469-495. https://doi.org/10.1002/mrm.30091

Accurate assessment of cerebral perfusion is vital for understanding the hemodynamic processes involved in various neurological disorders and guiding clinical decision-making. This guidelines article provides a comprehensive overview of quantitative... Read More about Recommendations for quantitative cerebral perfusion MRI using multi‐timepoint arterial spin labeling: Acquisition, quantification, and clinical applications.

Impact of the COVID-19 pandemic on hospital episodes for falls and fractures associated with new-onset disability and frailty in England: a national cohort study (2024)
Journal Article
Thomas, S., Littleboy, K., Foubert, J., Nafilyan, V., Bannister, N., Routen, A., Morriss, R., Khunti, K., Armstrong, N., Gray, L. J., & Gordon, A. L. (2024). Impact of the COVID-19 pandemic on hospital episodes for falls and fractures associated with new-onset disability and frailty in England: a national cohort study. Age and Ageing, 53(4), Article afae071. https://doi.org/10.1093/ageing/afae071

Background: Older people with frailty are at risk of harm from immobility or isolation, yet data about how COVID-19 lockdowns affected them are limited. Falls and fractures are easily measurable adverse outcomes correlated with frailty. We investigat... Read More about Impact of the COVID-19 pandemic on hospital episodes for falls and fractures associated with new-onset disability and frailty in England: a national cohort study.

Real‐world persistence of multiple sclerosis disease‐modifying therapies (2024)
Journal Article
Tallantyre, E. C., Dobson, R., Froud, J. L. J., St John, F. A., Anderson, V. M., Arun, T., Buckley, L., Evangelou, N., Ford, H. L., Galea, I., George, S., Gray, O. M., Hibbert, A. M., Hu, M., Hughes, S. E., Ingram, G., Kalra, S., Lim, C. E., Mathews, J. T. M., McDonnell, G. V., …Robertson, N. P. (2024). Real‐world persistence of multiple sclerosis disease‐modifying therapies. European Journal of Neurology, 31(7), Article e16289. https://doi.org/10.1111/ene.16289

Background and purpose: Treatment persistence is the continuation of therapy over time. It reflects a combination of treatment efficacy and tolerability. We aimed to describe real‐world rates of persistence on disease‐modifying therapies (DMTs) for p... Read More about Real‐world persistence of multiple sclerosis disease‐modifying therapies.

Design of trials in lacunar stroke and cerebral small vessel disease: review and experience with the LACunar Intervention Trial 2 (LACI-2) (2024)
Journal Article
Blair, G., Appleton, J. P., Doubal, F. N., Mhlanga, I. I., Woodhouse, L. J., Bath, P. M., & Wardlaw, J. M. (2024). Design of trials in lacunar stroke and cerebral small vessel disease: review and experience with the LACunar Intervention Trial 2 (LACI-2). Stroke and Vascular Neurology, https://doi.org/10.1136/svn-2023-003022

Cerebral small vessel disease (cSVD) causes lacunar stroke (25% of ischaemic strokes), haemorrhage, dementia, physical frailty, or is 'covert', but has no specific treatment. Uncertainties about the design of clinical trials in cSVD, which patients t... Read More about Design of trials in lacunar stroke and cerebral small vessel disease: review and experience with the LACunar Intervention Trial 2 (LACI-2).

Used to be a dime, now it’s a dollar: R-SPiN keyword predictability revisited 40 years on (2024)
Journal Article
Whitley, A., Naylor, G., & Hadley, L. V. (2024). Used to be a dime, now it’s a dollar: R-SPiN keyword predictability revisited 40 years on. Journal of Speech, Language, and Hearing Research, 67(4), 1229-1242. https://doi.org/10.1044/2024_JSLHR-23-00615

Purpose:

Almost 40 years after its development, in this article, we reexamine the relevance and validity of the ubiquitously used Revised Speech Perception in Noise (R-SPiN) sentence corpus. The R-SPiN corpus includes “high-context” and “low-conte... Read More about Used to be a dime, now it’s a dollar: R-SPiN keyword predictability revisited 40 years on.

Typology of employers offering line manager training for mental health (2024)
Journal Article
Blake, H., Hassard, J., Dulal-Arthur, T., Wishart, M., Roper, S., Bourke, J., …Thomson, L. (2024). Typology of employers offering line manager training for mental health. Occupational Medicine, 74(3), 242-250. https://doi.org/10.1093/occmed/kqae025

Background Mental ill health has a high economic impact on society and employers. National and international policy advocates line manager (LM) training in mental health as a key intervention, but little is known about employer training provisions. A... Read More about Typology of employers offering line manager training for mental health.

Predictability of intelligence and age from structural connectomes (2024)
Journal Article
Kopetzky, S. J., Li, Y., Kaiser, M., & Butz-Ostendorf, M. (2024). Predictability of intelligence and age from structural connectomes. PLoS ONE, 19(4), Article e0301599. https://doi.org/10.1371/journal.pone.0301599

In this study, structural images of 1048 healthy subjects from the Human Connectome Project Young Adult study and 94 from ADNI-3 study were processed by an in-house tractography pipeline and analyzed together with pre-processed data of the same subje... Read More about Predictability of intelligence and age from structural connectomes.

Precision computerised cognitive behavioural therapy (cCBT) for adolescents with depression: a pilot and feasibility randomised controlled trial protocol for SPARX-UK (2024)
Journal Article
Khan, K., Hall, C. L., Babbage, C., Dodzo, S., Greenhalgh, C., Lucassen, M., …Hollis, C. (2024). Precision computerised cognitive behavioural therapy (cCBT) for adolescents with depression: a pilot and feasibility randomised controlled trial protocol for SPARX-UK. Pilot and Feasibility Studies, 10(1), Article 53. https://doi.org/10.1186/s40814-024-01475-7

Background : A serious game called SPARX (Smart, Positive, Active, Realistic, X-factor thoughts), originally developed in New Zealand and incorporating cognitive behavioural therapy (CBT) principles, has been shown to help reduce symptoms of depressi... Read More about Precision computerised cognitive behavioural therapy (cCBT) for adolescents with depression: a pilot and feasibility randomised controlled trial protocol for SPARX-UK.

Comparing the Prevalence of Psychiatric Disorders in Cohorts of Children Born Extremely Preterm in 1995 and 2006: The EPICure Studies (2024)
Journal Article
Larsen, J., Holland, J., Kochhar, P., Wolke, D., Draper, E. S., Marlow, N., & Johnson, S. (2024). Comparing the Prevalence of Psychiatric Disorders in Cohorts of Children Born Extremely Preterm in 1995 and 2006: The EPICure Studies. Journal of the American Academy of Child and Adolescent Psychiatry, 2(3), 217-228. https://doi.org/10.1016/j.jaacop.2024.02.005

Objective: This study aimed to identify the prevalence of psychiatric disorders in two population-based cohorts of children born extremely preterm (EP) 11 years apart to ascertain if psychiatric outcomes have changed over time following improved surv... Read More about Comparing the Prevalence of Psychiatric Disorders in Cohorts of Children Born Extremely Preterm in 1995 and 2006: The EPICure Studies.

The impact of the COVID-19 pandemic on children and adolescent mental health inpatient service use in England: An interrupted time-series analysis of national patient records (2024)
Journal Article
Tsiachristas, A., Holland, J., Guo, B., Chitsabesan, P., Sayal, K., & Pari, A. A. A. (2024). The impact of the COVID-19 pandemic on children and adolescent mental health inpatient service use in England: An interrupted time-series analysis of national patient records. BJPsych Open, 10(2), Article e69. https://doi.org/10.1192/bjo.2024.9

Background:

During the initial phases of the COVID 19 pandemic children and young people (CYP) faced significant restrictions. The virus and mitigation approaches significantly impacted how health services could function, and be safely delivered.... Read More about The impact of the COVID-19 pandemic on children and adolescent mental health inpatient service use in England: An interrupted time-series analysis of national patient records.