Outputs (2)

Ocrelizumab B cell depletion has no effect on HERV RNA expression in PBMC in MS patients (2023)
Preprint / Working Paper
Tarlinton, R., Tanescu, R., Shannon-Lowe, C., & Gran, B. (2023). Ocrelizumab B cell depletion has no effect on HERV RNA expression in PBMC in MS patients

Background Epstein Barr Virus (EBV) infection of B cells is now understood to be one of the triggering events for the development of Multiple Sclerosis (MS), a progressive immune-mediated disease of the central nervous system. EBV infection is also l... Read More about Ocrelizumab B cell depletion has no effect on HERV RNA expression in PBMC in MS patients.

ADAMS project: a genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis based in the UK. (2023)
Journal Article
Jacobs, B. M., Schalk, L., Dunne, A., Scalfari, A., Nandoskar, A., Gran, B., Mein, C. A., Sellers, C., Spilker, C., Rog, D., Visentin, E., Bezzina, E. L., Uzochukwu, E., Tallantyre, E., Wozniak, E., Sacre, E., Hassan-Smith, G., Ford, H. L., Harris, J., Bradley, J., …Dobson, R. (2023). ADAMS project: a genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis based in the UK. BMJ Open, 13(5), Article e071656. https://doi.org/10.1136/bmjopen-2023-071656

Purpose Genetic studies of multiple sclerosis (MS) susceptibility and severity have focused on populations of European ancestry. Studying MS genetics in other ancestral groups is necessary to determine the generalisability of these findings. The gene... Read More about ADAMS project: a genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis based in the UK..