Outputs (14)

Using Oscillation to Improve the Insertion Depth and Consistency of Hollow Microneedles for Transdermal Insulin Delivery with Mechanistic Insights (2024)
Journal Article
Smith, F., Kotowska, A. M., Fiedler, B., Cerny, E., Cheung, K., Rutland, C. S., Chowdhury, F., Segal, J., Rawson, F. J., & Marlow, M. (2025). Using Oscillation to Improve the Insertion Depth and Consistency of Hollow Microneedles for Transdermal Insulin Delivery with Mechanistic Insights. Molecular Pharmaceutics, 22(1), 316-329. https://doi.org/10.1021/acs.molpharmaceut.4c00942

Microneedles (MNs) offer the potential for discrete and painless transdermal drug delivery, yet poor insertion and dosing consistency have hindered their clinical translation. Specifically, hollow MNs are appropriate for the administration of liquid... Read More about Using Oscillation to Improve the Insertion Depth and Consistency of Hollow Microneedles for Transdermal Insulin Delivery with Mechanistic Insights.

Methodology for Digital Transformation: A Continuous Improvement Approach (2023)
Presentation / Conference Contribution
Hernández Oliver, K., Martínez-Arellano, G., & Segal, J. (2023, September). Methodology for Digital Transformation: A Continuous Improvement Approach. Presented at 1st Workshop on Low-Cost Digital Solutions for Industrial Automation, Cambridge, UK

Digital technologies have the potential to significantly transform the manufacturing industry by achieving improvements in productivity, quality and sustainability. Despite this, the uptake is relatively low as companies face a number of challenges i... Read More about Methodology for Digital Transformation: A Continuous Improvement Approach.

Low-cost System for Visual Inspection of Corrosion: An Industrial Case Study (2023)
Presentation / Conference Contribution
Hernández Oliver, K. H., Martínez-Arellano, G., & Segal, J. (2023, September). Low-cost System for Visual Inspection of Corrosion: An Industrial Case Study. Presented at 1st Workshop on Low-Cost Digital Solutions for Industrial Automation, Cambridge, UK

The use of digital technologies around the world has increased considerably, modifying the way in which daily activities are conducted. The manufacturing sector is no exception. Over the last decade, digital technologies have become a key element for... Read More about Low-cost System for Visual Inspection of Corrosion: An Industrial Case Study.

Development of a Cubesat Platform for Biomedical and Pharmaceutical LEO Experiments (2020)
Presentation / Conference Contribution
Robson, D., Cappelletti, C., Segal, J., Williams, P., & Szewczyk, N. (2020, January). Development of a Cubesat Platform for Biomedical and Pharmaceutical LEO Experiments. Presented at Fifth IAA Conference on Dynamics and Control of Space Systems, Rome, Italy

Undertaking biology experiments in space is a necessary and important part of understanding evolution, adaption, and ageing, and crucial to the enablement of safe human exploration away from Earth. Access to space, however, is difficult, costly and r... Read More about Development of a Cubesat Platform for Biomedical and Pharmaceutical LEO Experiments.

Intradermal delivery of imiquimod using polymeric microneedles for basal cell carcinoma (2020)
Journal Article
Sabri, A. H., Cater, Z., Gurnani, P., Ogilvie, J., Segal, J., Scurr, D. J., & Marlow, M. (2020). Intradermal delivery of imiquimod using polymeric microneedles for basal cell carcinoma. International Journal of Pharmaceutics, 589, Article 119808. https://doi.org/10.1016/j.ijpharm.2020.119808

Despite being one of the most efficacious drugs used in the treatment of basal cell carcinoma (BCC), imiquimod has limited cutaneous permeation. The current work presents the development of polyvinylpyrrolidone-co-vinyl acetate (PVPVA) microneedles l... Read More about Intradermal delivery of imiquimod using polymeric microneedles for basal cell carcinoma.

Intradermal Delivery of an Immunomodulator for Basal Cell Carcinoma; Expanding the Mechanistic Insight into Solid Microneedle-Enhanced Delivery of Hydrophobic Molecules (2020)
Journal Article
Sabri, A., Ogilvie, J., McKenna, J., Segal, J., Scurr, D., & Marlow, M. (2020). Intradermal Delivery of an Immunomodulator for Basal Cell Carcinoma; Expanding the Mechanistic Insight into Solid Microneedle-Enhanced Delivery of Hydrophobic Molecules. Molecular Pharmaceutics, 17(8), 2925–2937. https://doi.org/10.1021/acs.molpharmaceut.0c00347

Basal cell carcinoma (BCC) is the most common cutaneous malignancy in humans. One of the most efficacious drugs used in the management of BCC is the immunomodulator, imiquimod. However, imiquimod has physiochemical properties that limit its permeatio... Read More about Intradermal Delivery of an Immunomodulator for Basal Cell Carcinoma; Expanding the Mechanistic Insight into Solid Microneedle-Enhanced Delivery of Hydrophobic Molecules.

Characterisation of mechanical insertion of commercial microneedles (2020)
Journal Article
Sabri, A. H., Cater, Z., Ogilvie, J., Scurr, D. J., Marlow, M., & Segal, J. (2020). Characterisation of mechanical insertion of commercial microneedles. Journal of Drug Delivery Science and Technology, 58, Article 101766. https://doi.org/10.1016/j.jddst.2020.101766

The protection provided by the human skin is mostly attributed to the stratum corneum. However, this barrier also limits the range of molecules that can be delivered into and across the skin. One of the methods to overcome this physiological barrier... Read More about Characterisation of mechanical insertion of commercial microneedles.

Multi-material 3D bioprinting of porous constructs for cartilage regeneration (2019)
Journal Article
Ruiz-Cantu, L., Gleadall, A., Faris, C., Segal, J., Shakesheff, K., & Yang, J. (2020). Multi-material 3D bioprinting of porous constructs for cartilage regeneration. Materials Science and Engineering: C, 109, Article 110578. https://doi.org/10.1016/j.msec.2019.110578

© 2020 Elsevier B.V. The current gold standard for nasal reconstruction after rhinectomy or severe trauma includes transposition of autologous cartilage grafts in conjunction with coverage using an autologous skin flap. Harvesting autologous cartilag... Read More about Multi-material 3D bioprinting of porous constructs for cartilage regeneration.

Improving children’s and their visitors’ hand hygiene compliance (2019)
Journal Article
Lary, D., Calvert, A., Nerlich, B., Segal, J., Vaughan, N., Randle, J., & Hardie, K. (2020). Improving children’s and their visitors’ hand hygiene compliance. Journal of Infection Prevention, 21(2), 60-67. https://doi.org/10.1177/1757177419892065

Background: Numerous interventions have tried to improve healthcare workers' hand hygiene compliance, however little attention has been paid to children's and their visitors’ compliance.
Aim: To increase children’s and visitors’ compliance using in... Read More about Improving children’s and their visitors’ hand hygiene compliance.

VOLCO: a predictive model for 3D printed microarchitecture (2018)
Journal Article
Gleadall, A., Ashcroft, I., & Segal, J. (in press). VOLCO: a predictive model for 3D printed microarchitecture. Additive Manufacturing, 21, https://doi.org/10.1016/j.addma.2018.04.004

Extrusion-based 3D printing is widely used for porous scaffolds in which polymer filaments are extruded in the form of log-pile structures. These structures are typically designed with the assumption that filaments have a continuous cylindrical profi... Read More about VOLCO: a predictive model for 3D printed microarchitecture.