Outputs (7)

Multiplexing projects: supervising undergraduate research projects with larger cohorts (2024)
Journal Article
Nisbet, R. E. R., Scott, D. J., & Campeotto, I. (2024). Multiplexing projects: supervising undergraduate research projects with larger cohorts. The Biochemist, 46(5), 18-23. https://doi.org/10.1042/BIO_2024_897

Almost all undergraduate students in the UK complete a final year research project or dissertation. In the molecular biosciences field, these projects are often based in individual research laboratory. However, with increasing student numbers, fallin... Read More about Multiplexing projects: supervising undergraduate research projects with larger cohorts.

Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5 (2024)
Journal Article
Harrison, T. E., Alam, N., Farrell, B., Quinkert, D., Lias, A. M., King, L. D., Barfod, L. K., Draper, S. J., Campeotto, I., & Higgins, M. K. (2024). Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5. EMBO Molecular Medicine, 16(10), 2539-2559. https://doi.org/10.1038/s44321-024-00123-0

There is an urgent need for improved malaria vaccine immunogens. Invasion of erythrocytes by Plasmodium falciparum is essential for its life cycle, preceding symptoms of disease and parasite transmission. Antibodies which target PfRH5 are highly effe... Read More about Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5.

Preclinical development of a stabilized RH5 virus-like particle vaccine that induces improved antimalarial antibodies (2024)
Journal Article
King, L. D., Pulido, D., Barrett, J. R., Davies, H., Quinkert, D., Lias, A. M., Silk, S. E., Pattinson, D. J., Diouf, A., Williams, B. G., McHugh, K., Rodrigues, A., Rigby, C. A., Strazza, V., Suurbaar, J., Rees-Spear, C., Dabbs, R. A., Ishizuka, A. S., Zhou, Y., Gupta, G., …Draper, S. J. (2024). Preclinical development of a stabilized RH5 virus-like particle vaccine that induces improved antimalarial antibodies. Cell Reports Medicine, 5(7), Article 101654. https://doi.org/10.1016/j.xcrm.2024.101654

Plasmodium falciparum reticulocyte-binding protein homolog 5 (RH5) is a leading blood-stage malaria vaccine antigen target, currently in a phase 2b clinical trial as a full-length soluble protein/adjuvant vaccine candidate called RH5.1/Matrix-M. We i... Read More about Preclinical development of a stabilized RH5 virus-like particle vaccine that induces improved antimalarial antibodies.

The Potential of Plant-Produced Virus-like Particle Vaccines for African Horse Sickness and Other Equine Orbiviruses (2024)
Journal Article
Pitchers, K. G., Boakye, O. D., Campeotto, I., & Daly, J. M. (2024). The Potential of Plant-Produced Virus-like Particle Vaccines for African Horse Sickness and Other Equine Orbiviruses. Pathogens, 13(6), Article 458. https://doi.org/10.3390/pathogens13060458

African horse sickness is a devastating viral disease of equids. It is transmitted by biting midges of the genus Culicoides with mortalities reaching over 90% in naïve horses. It is endemic to sub-Saharan Africa and is seasonally endemic in many part... Read More about The Potential of Plant-Produced Virus-like Particle Vaccines for African Horse Sickness and Other Equine Orbiviruses.

Open and closed conformations of a sub-80 kDa Chagas vaccine candidate defined by a cryo-EM led integrative approach (2024)
Preprint / Working Paper
Batra, S., Ragan, T. J., Frank, A. M., Kaplan, M., Lancey, C., Assadipapari, M., Ying, C., Struwe, W. B., Hesketh, E., Barfod, L., & Campeotto, I. Open and closed conformations of a sub-80 kDa Chagas vaccine candidate defined by a cryo-EM led integrative approach

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, remains a significant global public health concern. It affects an estimated eight million individuals worldwide, with the majority remaining undiagnosed. Despite its profound health... Read More about Open and closed conformations of a sub-80 kDa Chagas vaccine candidate defined by a cryo-EM led integrative approach.

Preclinical Development of a Stabilized RH5 Virus-Like Particle Vaccine that Induces Improved Anti-Malarial Antibodies (2024)
Preprint / Working Paper
King, L. D. W., Pulido, D., Barrett, J. R., Davies, H., Quinkert, D., Lias, A. M., Silk, S. E., Pattinson, D. J., Diouf, A., Williams, B. G., McHugh, K., Rodrigues, A., Rigby, C. A., Strazza, V., Suurbaar, J., Rees-Spear, C., Dabbs, R. A., Ishizuka, A. S., Zhou, Y., Gupta, G., …Draper, S. J. (2024). Preclinical Development of a Stabilized RH5 Virus-Like Particle Vaccine that Induces Improved Anti-Malarial Antibodies

The development of a highly effective vaccine against the pathogenic blood-stage infection of human malaria will require a delivery platform that can induce an antibody response of both maximal quantity and functional quality. One strategy to achieve... Read More about Preclinical Development of a Stabilized RH5 Virus-Like Particle Vaccine that Induces Improved Anti-Malarial Antibodies.

Protein-to-structure pipeline for ambient-temperature in situ crystallography at VMXi (2023)
Journal Article
Mikolajek, H., Sanchez-Weatherby, J., Sandy, J., Gildea, R. J., Campeotto, I., Cheruvara, H., Clarke, J. D., Foster, T., Fujii, S., Paulsen, I. T., Shah, B. S., & Hough, M. A. (2023). Protein-to-structure pipeline for ambient-temperature in situ crystallography at VMXi. IUCrJ, 10(4), 420-429. https://doi.org/10.1107/s2052252523003810

The utility of X-ray crystal structures determined under ambient-temperature conditions is becoming increasingly recognized. Such experiments can allow protein dynamics to be characterized and are particularly well suited to challenging protein targe... Read More about Protein-to-structure pipeline for ambient-temperature in situ crystallography at VMXi.