Outputs (31)

Maternal obesity during pregnancy leads to derangements in one-carbon metabolism and the gut microbiota: implications for fetal development and offspring wellbeing (2022)
Journal Article
Rubini, E., Schenkelaars, N., Rousian, M., Sinclair, K. D., Wekema, L., Faas, M. M., Steegers-Theunissen, R. P., & Schoenmakers, S. (2022). Maternal obesity during pregnancy leads to derangements in one-carbon metabolism and the gut microbiota: implications for fetal development and offspring wellbeing. American Journal of Obstetrics and Gynecology, 227(3), 392-400. https://doi.org/10.1016/j.ajog.2022.04.013

A healthy diet prior to and during pregnancy is beneficial in acquiring essential B vitamins involved in one-carbon metabolism, and to maintain a healthy gut microbiota. Each play important roles in fetal development, immune-system remodeling and pre... Read More about Maternal obesity during pregnancy leads to derangements in one-carbon metabolism and the gut microbiota: implications for fetal development and offspring wellbeing.

Integrating heterogeneous across-country data for proxy-based random forest prediction of enteric methane in dairy cattle (2022)
Journal Article
Negussie, E., González-Recio, O., Battagin, M., Bayat, A.-R., Boland, T., de Haas, Y., Garcia-Rodriguez, A., Garnsworthy, P. C., Gengler, N., Kreuzer, M., Kuhla, B., Lassen, J., Peiren, N., Pszczola, M., Schwarm, A., Soyeurt, H., Vanlierde, A., Yan, T., & Biscarini, F. (2022). Integrating heterogeneous across-country data for proxy-based random forest prediction of enteric methane in dairy cattle. Journal of Dairy Science, 105(6), 5124-5140. https://doi.org/10.3168/jds.2021-20158

Direct measurements of methane (CH4) from individual animals are difficult and expensive. Predictions based on proxies for CH4 are a viable alternative. Most prediction models are based on multiple linear regressions (MLR) and predictor variables tha... Read More about Integrating heterogeneous across-country data for proxy-based random forest prediction of enteric methane in dairy cattle.

In vitro culture of ovine embryos up to early gastrulating stages (2022)
Journal Article
Ramos-Ibeas, P., González-Brusi, L., Used, M. T., Cocero, M. J., Marigorta, P., Alberio, R., & Bermejo-Álvarez, P. (2022). In vitro culture of ovine embryos up to early gastrulating stages. Development, 149(6), Article dev199743. https://doi.org/10.1242/dev.199743

Developmental failures occurring shortly after blastocyst hatching from the zona pellucida constitute a major cause of pregnancy losses in both humans and farm ungulates. The developmental events occurring following hatching in ungulates include the... Read More about In vitro culture of ovine embryos up to early gastrulating stages.

89. Challenges and opportunities for farmers and calf rearers (2022)
Journal Article
Margerison, J. (2022). 89. Challenges and opportunities for farmers and calf rearers. Animal - Science proceedings, 13(1), 61-62. https://doi.org/10.1016/j.anscip.2022.03.090

Farmers and calf rearers aim to enhance animal health through disease prevention strategies included in herd health plans, which include investment in housing, biosecurity, hygiene and staff training that lower the cost of treatment (morbidity), labo... Read More about 89. Challenges and opportunities for farmers and calf rearers.

Tig1 regulates proximo-distal identity during salamander limb regeneration (2022)
Journal Article
Oliveira, C. R., Knapp, D., Elewa, A., Gerber, T., Gonzalez Malagon, S. G., Gates, P. B., Walters, H. E., Petzold, A., Arce, H., Cordoba, R. C., Subramanian, E., Chara, O., Tanaka, E. M., Simon, A., & Yun, M. H. (2022). Tig1 regulates proximo-distal identity during salamander limb regeneration. Nature Communications, 13(1), Article 1141. https://doi.org/10.1038/s41467-022-28755-1

Salamander limb regeneration is an accurate process which gives rise exclusively to the missing structures, irrespective of the amputation level. This suggests that cells in the stump have an awareness of their spatial location, a property termed pos... Read More about Tig1 regulates proximo-distal identity during salamander limb regeneration.

Photosensitivity and cGAS-Dependent IFN-1 Activation in Patients with Lupus and TREX1 Deficiency (2022)
Journal Article
Berndt, N., Wolf, C., Fischer, K., Cura Costa, E., Knuschke, P., Zimmermann, N., Schmidt, F., Merkel, M., Chara, O., Lee-Kirsch, M. A., & Günther, C. (2022). Photosensitivity and cGAS-Dependent IFN-1 Activation in Patients with Lupus and TREX1 Deficiency. Journal of Investigative Dermatology, 142(3), 633-640.e6. https://doi.org/10.1016/j.jid.2021.04.037

The exonuclease TREX1 safeguards the cells against DNA accumulation in the cytosol and thereby prevents innate immune activation and autoimmunity. TREX1 mutations lead to chronic DNA damage and cell-intrinsic IFN-1 response. Associated disease phenot... Read More about Photosensitivity and cGAS-Dependent IFN-1 Activation in Patients with Lupus and TREX1 Deficiency.

Ovine fetal testis stage-specific sensitivity to environmental chemical mixtures (2022)
Journal Article
Lea, R. G., Mandon-Pépin, B., Loup, B., Poumerol, E., Jouneau, L., Egbowon, B. F., Bowden, A., Cotinot, C., Purdie, L., Zhang, Z., Fowler, P. A., & Sinclair, K. D. (2022). Ovine fetal testis stage-specific sensitivity to environmental chemical mixtures. Reproduction, 163(2), 119-131. https://doi.org/10.1530/REP-21-0235

Exposure of the fetal testis to numerous individual environmental chemicals (ECs) is frequently associated with dysregulated development, leading to impaired adult reproductive competence. However, 'real-life' exposure involves complex mixtures of EC... Read More about Ovine fetal testis stage-specific sensitivity to environmental chemical mixtures.

Size matters: tissue size as a marker for a transition between reaction–diffusion regimes in spatio-temporal distribution of morphogens (2022)
Journal Article
Ceccarelli, A. S., Borges, A., & Chara, O. (2022). Size matters: tissue size as a marker for a transition between reaction–diffusion regimes in spatio-temporal distribution of morphogens. Royal Society Open Science, 9(1), Article 211112. https://doi.org/10.1098/rsos.211112

The reaction–diffusion model constitutes one of the most influential mathematical models to study distribution of morphogens in tissues. Despite its widespread use, the effect of finite tissue size on model-predicted spatio-temporal morphogen distrib... Read More about Size matters: tissue size as a marker for a transition between reaction–diffusion regimes in spatio-temporal distribution of morphogens.

Epigenetic regulation of 5α reductase-1 underlies adaptive plasticity of reproductive function and pubertal timing (2022)
Journal Article
Bar-Sadeh, B., Amichai, O. E., Pnueli, L., Begum, K., Leeman, G., Emes, R. D., Stöger, R., Bentley, G. R., & Melamed, P. (2022). Epigenetic regulation of 5α reductase-1 underlies adaptive plasticity of reproductive function and pubertal timing. BMC Biology, 20, Article 11. https://doi.org/10.1186/s12915-021-01219-6

Background: Women facing increased energetic demands in childhood commonly have altered adult ovarian activity and shorter reproductive lifespan, possibly comprising a strategy to optimize reproductive success. Here, we sought to understand the mecha... Read More about Epigenetic regulation of 5α reductase-1 underlies adaptive plasticity of reproductive function and pubertal timing.

Biofortified Maize Improves Selenium Status of Women and Children in a Rural Community in Malawi: Results of the Addressing Hidden Hunger With Agronomy Randomized Controlled Trial (2022)
Journal Article
Joy, E. J., Kalimbira, A. A., Sturgess, J., Banda, L., Chiutsi-Phiri, G., Manase, H., Gondwe, J., Ferguson, E. L., Kalumikiza, Z., Bailey, E. H., Young, S. D., Matandika, L., Mfutso-Bengo, J., Millar, K., Niksic, M., Segovia de la Revilla, L., Likoswe, B. H., Phuka, J. C., Phiri, F. P., Lark, R. M., …Allen, E. (2022). Biofortified Maize Improves Selenium Status of Women and Children in a Rural Community in Malawi: Results of the Addressing Hidden Hunger With Agronomy Randomized Controlled Trial. Frontiers in Nutrition, 8, Article 788096. https://doi.org/10.3389/fnut.2021.788096

Background: Selenium deficiency is widespread in the Malawi population. The selenium concentration in maize, the staple food crop of Malawi, can be increased by applying selenium-enriched fertilizers. It is unknown whether this strategy, called agron... Read More about Biofortified Maize Improves Selenium Status of Women and Children in a Rural Community in Malawi: Results of the Addressing Hidden Hunger With Agronomy Randomized Controlled Trial.